肝移植前的移植物预处理
Graft Reconditioning before Liver Transplantation.
作者信息
Hoyer Dieter P, Minor Thomas
机构信息
General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany.
出版信息
Visc Med. 2016 Aug;32(4):250-256. doi: 10.1159/000446378. Epub 2016 Jul 29.
BACKGROUND
The high demand for livers for transplantation has led to organs of limited quality being accepted to expand the donor pool. This is associated with inferior outcomes due to more pronounced preservation injury. Accordingly, recent research has aimed to develop preservation modalities for improved preservation as well as strategies for liver viability assessment and liver reconditioning.
METHODS
The PubMed database was searched using the terms 'perfusion', 'liver', 'preservation', and 'reconditioning' in various combinations, and the according literature was reviewed.
RESULTS
Several perfusion techniques have been developed in recent years with the potential for liver reconditioning. Preclinical and first emerging clinical data suggest feasibility, safety, and superiority over the current gold standard of cold storage.
CONCLUSION
This review outlines current advances in the field of liver preservation with an emphasis on liver reconditioning methods.
背景
对肝脏移植的高需求导致质量有限的器官也被纳入供体库以扩大供体来源。这与更严重的保存损伤导致的较差结果相关。因此，最近的研究旨在开发改善保存的保存方式以及肝脏活力评估和肝脏修复策略。
方法
使用“灌注”“肝脏”“保存”和“修复”等术语的各种组合在PubMed数据库中进行检索，并对相关文献进行综述。
结果
近年来已开发出几种具有肝脏修复潜力的灌注技术。临床前和初步出现的临床数据表明其具有可行性、安全性，且优于当前的冷保存金标准。
结论
本综述概述了肝脏保存领域的当前进展，重点是肝脏修复方法。
Zotero 插件