Capehart Stacy L, Carlson Erin E
Department of Chemistry, University of Minnesota, 207 Pleasant St., SE Minneapolis, 55455-0431, USA.
Chem Commun (Camb). 2016 Nov 3;52(90):13229-13232. doi: 10.1039/c6cc07111b.
Natural products are privileged scaffolds due to their high propensity to possess bioactivity. To expedite discovery of thiol-containing compounds, we devised a selective solid-supported reagent for their immobilization, followed by cleavage of a photocleavable linker to yield stable natural product conjugates for direct detection by mass spectrometry. Importantly, the natural products can also be tracelessly released to yield the native structures for chemical and biological evaluation.
