School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Nanoscale. 2016 Oct 6;8(39):17241-17249. doi: 10.1039/c6nr05943k.
In this work, we designed a new hybrid nanogel with redox responsive polymer gel shells and mesoporous silica nanoparticles (MSNs) cores via laccase-mediated radical polymerization. The successful coating of the responsive gel shells on the MSNs was confirmed by the morphology and increased diameters of the particles as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS). As observed by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), the presence of the element S around the MSNs further confirmed the formation of the gel shell. When loaded with doxorubicin (DOX), these hybrid nanogels had a significantly higher cumulative DOX release in a reductive environment than that found under physiological conditions. The MSNs with mesoporous channels were loaded with perfluorohexane (PFH) for ultrasound imaging, which was enhanced by the presence of the elastic gel shells.
在这项工作中，我们通过漆酶介导的自由基聚合，设计了一种具有氧化还原响应聚合物凝胶壳和介孔硅纳米粒子（MSNs）核的新型杂化纳米凝胶。通过透射电子显微镜（TEM）和动态光散射（DLS）确定的颗粒形态和直径的增加，证实了响应性凝胶壳的成功包覆。通过扫描透射电子显微镜（STEM）和能谱（EDS）观察到，MSNs 周围 S 元素的存在进一步证实了凝胶壳的形成。当负载多柔比星（DOX）时，这些杂化纳米凝胶在还原环境下的 DOX 累积释放量明显高于生理条件下的释放量。具有介孔通道的 MSNs 被全氟己烷（PFH）加载用于超声成像，弹性凝胶壳的存在增强了超声成像效果。
