硫醇酸三乙铵与肼的级联双环化反应：高效合成吡唑并[3,4-c]喹啉
Cascade bicyclization of triethylammonium thiolates with hydrazines: efficient access to pyrazolo[3,4-c]quinolines.
作者信息
Fan Wei, Li Yan-Rong, Jiang Bo, Li Guigen
机构信息
Institute of Chemistry & BioMedical Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing, 210093, P. R. China.
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA and School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China.
出版信息
Org Biomol Chem. 2016 Sep 26;14(38):9080-9087. doi: 10.1039/c6ob01728b.
Abstract
A new bicyclization strategy has been established, allowing a flexible and practical approach to 33 examples of pyrazolo[3,4-c]quinolines from low-cost and readily accessible triethylammonium thiolates with hydrazines. Notably, the features of this work include broad functional group compatibility, mild reaction conditions and good reaction yields.
摘要
一种新的双环化策略已经建立，它提供了一种灵活且实用的方法，可从低成本且易于获得的硫代三乙铵与肼出发，制备33个吡唑并[3,4-c]喹啉实例。值得注意的是，这项工作的特点包括广泛的官能团兼容性、温和的反应条件和良好的反应产率。
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