Gao Qian, Zhou Peng, Liu Feng, Hao Wen-Juan, Yao Changsheng, Jiang Bo, Tu Shu-Jiang
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P. R. China.
Chem Commun (Camb). 2015 Jun 11;51(46):9519-22. doi: 10.1039/c5cc02754c.
The combination of Co(acac)2 and AgOTf enables the bimetallic relay catalysis reaction of 2-ethynylanilines and isocyanides, allowing easy and low-cost access to new densely functionalized pyrrolo[2,3-b]indoles. The reaction pathway involves a Co(acac)2-catalyzed double isocyanide insertion followed by a silver-enabled 1,3-dipolar cycloaddition. The synthetic utility of these bicycloaddition reactions results in subsequent C-C and C-N bond-forming events to rapidly build up molecular complexity.
乙酰丙酮钴（II）（Co(acac)2）和三氟甲磺酸银（AgOTf）的组合能够实现2-乙炔基苯胺与异腈的双金属接力催化反应，从而能够简便且低成本地获得新型的高度官能团化的吡咯并[2,3-b]吲哚。反应途径包括Co(acac)2催化的双异腈插入反应，随后是银介导的1,3-偶极环加成反应。这些双环加成反应的合成效用导致随后的碳-碳和碳-氮键形成事件，从而迅速增加分子复杂性。
