一种具有潜在抗炎活性的新型取代吡唑并[4,3-c]喹啉的简便合成方法。
A convenient synthesis of new substituted pyrazolo[4,3-c]quinolines with potential antiinflammatory activity.
作者信息
Mekheimer R
机构信息
Chemistry Department, Faculty of Science, Minia University, Egypt.
出版信息
Pharmazie. 1994 Jul;49(7):486-9.
PMID:8073058
Abstract
2,4-Dichloro-quinoline-3-carbonitrile 1 reacts with hydrazines to afford pyrazolo[4,3-c]quinolines 5a, b. The reaction of 5a with sodium azide; hydrogen/Pd; triethylorthoformate; cyclohexylamine; piperidine; morpholine and acetic anhydride resulted in the corresponding heterocyclic derivatives 6-15.
摘要
2,4-二氯喹啉-3-腈1与肼反应生成吡唑并[4,3-c]喹啉5a、b。5a与叠氮化钠、氢气/钯、原甲酸三乙酯、环己胺、哌啶、吗啉和乙酸酐反应生成相应的杂环衍生物6-15。
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