核酸酶活性作为乳腺癌的一种特异性生物标志物。

Nuclease activity as a specific biomarker for breast cancer.

作者信息

Hernandez Luiza I, Ozalp Veli Cengiz, Hernandez Frank J

机构信息

SOMAprobes S.L., Science and Technology Park of Gipuzkoa, San Sebastian, 20009, Spain.

出版信息

Chem Commun (Camb). 2016 Oct 25;52(83):12346-12349. doi: 10.1039/c6cc07108b. Epub 2016 Sep 30.

DOI:10.1039/c6cc07108b

PMID:27722495

Abstract

We report on the activity of nucleases derived from cancer cells as a means for specific targeting using nucleic acid probes (substrates). We hypothesize that cancer cells can be differentiated from healthy cells based on their nuclease activity profile, and thus, any method based on this property represents a novel alternative for diagnostic and therapeutic intervention.

摘要

我们报道了源自癌细胞的核酸酶的活性，以此作为使用核酸探针（底物）进行特异性靶向的一种手段。我们假设癌细胞可根据其核酸酶活性谱与健康细胞区分开来，因此，基于这一特性的任何方法都代表了诊断和治疗干预的一种新选择。