体内缺氧细胞放射增敏剂的测试。

Testing of hypoxic cell radiosensitizers in vivo.

作者信息

Rauth A M, Chin J, Marchow L, Paciga J

出版信息

Br J Cancer Suppl. 1978 Jun;3:202-5.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149425/

Abstract

Use has been made of the transplantable KHT sarcoma in C3H mice to test the in vivo effectiveness of some 2-, 4-, and 5-nitroimidazoles as hypoxic cell radiosensitizers. A comparison of the in vivo versus the in vitro sensitizing ability of misonidazole and metronidazole indicates some differences, probably due to drug delivery problems in vivo. The relative sensitizing abilities of eight 2-nitroimidazoles, two 4-nigroimidazoles and two 5-nitroimidazoles are compared on the basis of the amount of drug injected and the plasma levels obtained.

摘要

利用C3H小鼠体内可移植的KHT肉瘤来测试一些2-、4-和5-硝基咪唑作为乏氧细胞放射增敏剂的体内有效性。米索硝唑和甲硝唑体内与体外增敏能力的比较表明存在一些差异，这可能是由于体内的药物递送问题所致。基于注射药物的量和所获得的血浆水平，对8种2-硝基咪唑、2种4-硝基咪唑和2种5-硝基咪唑的相对增敏能力进行了比较。

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Testing of hypoxic cell radiosensitizers in vivo.体内缺氧细胞放射增敏剂的测试。

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8

The effect of misonidazole in combination with radiation dose fractionation.米索硝唑与放射剂量分割联合应用的效果。

Br J Cancer Suppl. 1978 Jun;3:255-8.

本文引用的文献

1

Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice.

J Natl Cancer Inst. 1975 Nov;55(5):1189-94. doi: 10.1093/jnci/55.5.1189.

2

Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.用硝基咪唑类药物甲硝唑和Ro 7-0582对小鼠肿瘤缺氧细胞进行选择性放射增敏。

Radiat Res. 1975 Dec;64(3):633-47.

3

In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.使用肺集落技术通过KHT小鼠肿瘤对缺氧放射增敏剂进行体内测试。

Br J Radiol. 1975 Mar;48(567):209-20. doi: 10.1259/0007-1285-48-567-209.

4

Radiosensitizers of hypoxic cells in solid tumors.实体瘤中乏氧细胞的放射增敏剂

Cancer Treat Rev. 1976 Dec;3(4):227-56. doi: 10.1016/s0305-7372(76)80012-6.

5

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.亲电子致敏作用。VII. 硝基咪唑类作为乏氧细胞放射增敏剂的结构、单电子还原电位与效率之间的相关性。

Radiat Res. 1976 Jul;67(1):9-20.

6

Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.二甲基亚砜和乏氧细胞放射增敏剂对KHT小鼠肿瘤体内辐射反应的影响。

Radiat Res. 1977 Feb;69(2):248-57.

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