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体内缺氧细胞放射增敏剂的测试。

Testing of hypoxic cell radiosensitizers in vivo.

作者信息

Rauth A M, Chin J, Marchow L, Paciga J

出版信息

Br J Cancer Suppl. 1978 Jun;3:202-5.

PMID:277228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149425/
Abstract

Use has been made of the transplantable KHT sarcoma in C3H mice to test the in vivo effectiveness of some 2-, 4-, and 5-nitroimidazoles as hypoxic cell radiosensitizers. A comparison of the in vivo versus the in vitro sensitizing ability of misonidazole and metronidazole indicates some differences, probably due to drug delivery problems in vivo. The relative sensitizing abilities of eight 2-nitroimidazoles, two 4-nigroimidazoles and two 5-nitroimidazoles are compared on the basis of the amount of drug injected and the plasma levels obtained.

摘要

利用C3H小鼠体内可移植的KHT肉瘤来测试一些2-、4-和5-硝基咪唑作为乏氧细胞放射增敏剂的体内有效性。米索硝唑和甲硝唑体内与体外增敏能力的比较表明存在一些差异，这可能是由于体内的药物递送问题所致。基于注射药物的量和所获得的血浆水平，对8种2-硝基咪唑、2种4-硝基咪唑和2种5-硝基咪唑的相对增敏能力进行了比较。

相似文献

1
Testing of hypoxic cell radiosensitizers in vivo.体内缺氧细胞放射增敏剂的测试。
Br J Cancer Suppl. 1978 Jun;3:202-5.
2
Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.二甲基亚砜和乏氧细胞放射增敏剂对KHT小鼠肿瘤体内辐射反应的影响。
Radiat Res. 1977 Feb;69(2):248-57.
3
The effect of misonidazole in combination with radiation dose fractionation.米索硝唑与放射剂量分割联合应用的效果。
Br J Cancer Suppl. 1978 Jun;3:255-8.
4
The nitroimidazoles as radiosensitizers and cytotoxic agents.作为放射增敏剂和细胞毒剂的硝基咪唑类药物。
Br J Cancer Suppl. 1978 Jun;3:120-3.
5
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.使用肺集落技术通过KHT小鼠肿瘤对缺氧放射增敏剂进行体内测试。
Br J Radiol. 1975 Mar;48(567):209-20. doi: 10.1259/0007-1285-48-567-209.
6
Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo.缺氧细胞放射增敏剂：使用体内表皮细胞存活率对某些亲电子化合物进行的对比试验。
Radiat Res. 1974 Oct;60(1):119-32.
7
Cytotoxic and radiosensitizing effects of hypoxic cell sensitizers on EMT6 mouse mammary tumour cells in vivo and in vitro.乏氧细胞增敏剂对EMT6小鼠乳腺肿瘤细胞的体内外细胞毒性及放射增敏作用
Br J Cancer Suppl. 1978 Jun;3:212-5.
8
Effects of oxygen and misonidazole on cell transformation and cell killing in C3H 10T1/2 cells by X rays in vitro.氧气和米索硝唑对X射线体外诱导C3H 10T1/2细胞转化及细胞杀伤的影响。
Radiat Res. 1984 Oct;100(1):96-103.
9
[Toxic and radiosensitizing effect of reduced nitroimidazoles on E. coli B/r cells].[还原型硝基咪唑对大肠杆菌B/r细胞的毒性及放射增敏作用]
Radiobiologiia. 1983 Jul-Aug;23(4):505-9.
10
In vivo assay of the radiation sensitivity of hypoxic tumour cells; influence of gamma-rays cyclotron neutrons, misonidazole, hyperthermia and mixed modalities.乏氧肿瘤细胞辐射敏感性的体内测定；γ射线、回旋加速器中子、米索硝唑、热疗及联合治疗方式的影响
Br J Cancer Suppl. 1978 Jun;3:194-7.

引用本文的文献

1
Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.通过 O-[18F]三氟乙基化合成肿瘤乏氧标志物 [18F]TFMISO 的放射合成，揭示了三氟乙基对甲苯磺酸酯和碘化物在与氧亲核试剂的区域化学反应性方面的显著差异。
Bioorg Med Chem. 2011 Apr 1;19(7):2287-97. doi: 10.1016/j.bmc.2011.02.026. Epub 2011 Feb 18.
2
Structure-pharmacokinetic relationships for misonidazole analogues in mice.米索硝唑类似物在小鼠体内的结构-药代动力学关系
Cancer Chemother Pharmacol. 1981;6(1):39-49. doi: 10.1007/BF00253009.
3
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.米索硝唑与化疗药物洛莫司汀的体内联合应用。
Br J Cancer. 1981 Mar;43(3):367-77. doi: 10.1038/bjc.1981.57.
4
A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.一项关于米索硝唑与盆腔放疗用于宫颈癌患者的I期研究。
Br J Cancer. 1982 Jun;45(6):860-8. doi: 10.1038/bjc.1982.138.
5
Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069.药物RSU-1069的体内和体外细胞毒性研究。
Br J Cancer. 1986 Jun;53(6):743-51. doi: 10.1038/bjc.1986.128.
6
Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions.在缺氧和无氧条件下，抗坏血酸阴离子可增强硝基芳香化合物的细胞毒性。
Br J Cancer. 1979 Mar;39(3):321-9. doi: 10.1038/bjc.1979.56.
7
Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.在小鼠肿瘤中测试乏氧细胞放射增敏剂时的药代动力学考量
Br J Cancer. 1979 Mar;39(3):310-20. doi: 10.1038/bjc.1979.55.
8
The effect of misonidazole in combination with radiation dose fractionation.米索硝唑与放射剂量分割联合应用的效果。
Br J Cancer Suppl. 1978 Jun;3:255-8.

本文引用的文献

1
Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice.
J Natl Cancer Inst. 1975 Nov;55(5):1189-94. doi: 10.1093/jnci/55.5.1189.
2
Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.用硝基咪唑类药物甲硝唑和Ro 7-0582对小鼠肿瘤缺氧细胞进行选择性放射增敏。
Radiat Res. 1975 Dec;64(3):633-47.
3
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.使用肺集落技术通过KHT小鼠肿瘤对缺氧放射增敏剂进行体内测试。
Br J Radiol. 1975 Mar;48(567):209-20. doi: 10.1259/0007-1285-48-567-209.
4
Radiosensitizers of hypoxic cells in solid tumors.实体瘤中乏氧细胞的放射增敏剂
Cancer Treat Rev. 1976 Dec;3(4):227-56. doi: 10.1016/s0305-7372(76)80012-6.
5
Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers.亲电子致敏作用。VII. 硝基咪唑类作为乏氧细胞放射增敏剂的结构、单电子还原电位与效率之间的相关性。
Radiat Res. 1976 Jul;67(1):9-20.
6
Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo.二甲基亚砜和乏氧细胞放射增敏剂对KHT小鼠肿瘤体内辐射反应的影响。
Radiat Res. 1977 Feb;69(2):248-57.