Hall E J, Miller R, Astro M, Rini F
Br J Cancer Suppl. 1978 Jun;3:120-3.
Using hamster cells in culture, the radiosensitizing and cytotoxic properties of 8 electron-affinic drugs have been compared. These include nitrofurans derivatives as well as 2 and 5-nitroimidazoles. Most work has been performed with misonidazole for which it appears that, at 37 degree C, the concentration of drug required to produce a given level of cell killing is inversely proportional to the square of the exposure time. Misonidazole was also compared with X-rays for its ability to produce neoplastic transformations in vitro, using the C3H 10T 1/2 cell line.
利用培养的仓鼠细胞，比较了8种亲电子药物的放射增敏和细胞毒性特性。这些药物包括硝基呋喃衍生物以及2-硝基咪唑和5-硝基咪唑。大多数研究是针对米索硝唑进行的，在37℃时，产生给定细胞杀伤水平所需的药物浓度似乎与照射时间的平方成反比。还使用C3H 10T 1/2细胞系，比较了米索硝唑与X射线在体外诱导肿瘤转化的能力。
