Sneddon综合征患者体内含免疫球蛋白M的免疫复合物和抗磷脂抗体。

IGM-containing immune complexes and antiphospholipid antibodies in patients with Sneddon's syndrome.

作者信息

Schulze-Lohoff E, Krapf F, Bleil L, Burmester G R, Kölble K, Nüsslein H G, Rödl W, Kalden J R

机构信息

Department for Clinical Immunology and Rheumatology, University of Erlangen-Nürnberg, Federal Republic of Germany.

出版信息

Rheumatol Int. 1989;9(1):43-8. doi: 10.1007/BF00270289.

DOI:10.1007/BF00270289

PMID:2772486

Abstract

We report three patients with a Sneddon syndrome in whom predominantly small (500-900 kD) IgM-containing serum immune complexes were detectable. Furthermore, antiphospholipid antibodies and increased von Willebrand factor antigen were found in the sera of two cases. Especially the data demonstrating small circulating immune complex as suggest that Sneddon's syndrome, a rare vasculitis disorder, might immunologically be characterized by circulating IgM-containing immune complexes which, in addition, could play a role in the pathogenesis of this disease entity. The elevated antiphospholipid antibodies as well as the increased von Willebrand factor antigen in the sera of the investigated patients have to be considered as nonspecific vasculitis-associated phenomena.

摘要

我们报告了3例Sneddon综合征患者，其血清中可检测到主要为小分子量（500 - 900 kD）的含IgM血清免疫复合物。此外，在2例患者的血清中发现了抗磷脂抗体和血管性血友病因子抗原增加。特别是有关小循环免疫复合物的数据表明，Sneddon综合征这种罕见的血管炎疾病，在免疫学上可能以循环含IgM免疫复合物为特征，此外，这些复合物可能在该疾病实体的发病机制中起作用。所研究患者血清中抗磷脂抗体升高以及血管性血友病因子抗原增加，必须被视为非特异性血管炎相关现象。