Braune S, Siekmann R, Vaith P, Lücking C H
Neurologische Universitätsklinik Freiburg, Germany.
Rheumatol Int. 1993;13(4):169-74. doi: 10.1007/BF00301266.
In two patients with primary antiphospholipid antibody syndrome and acute cerebrovascular ischemic events, local intraarterial fibrinolysis and intravenous heparin therapy, respectively, resulted in a limitation of persisting neurological deficits. On the basis of the 35 case reports available a combination of anticoagulation with warfarin, plus immunosuppression with steroids and/or cyclophosphamide or azathioprine, appears to be the best treatment to prevent further cerebral ischemic events. The therapeutic options are reviewed and discussed.
在两名患有原发性抗磷脂抗体综合征并发生急性脑血管缺血事件的患者中，分别采用局部动脉内纤维蛋白溶解术和静脉注射肝素治疗，均使持续性神经功能缺损得到了限制。根据现有的35例病例报告，华法林抗凝治疗联合类固醇和/或环磷酰胺或硫唑嘌呤免疫抑制治疗，似乎是预防进一步脑缺血事件的最佳治疗方法。本文对治疗选择进行了综述和讨论。
