缺氧细胞影响癌症治疗中治愈情况的确凿证据。
Definitive evidence for hypoxic cells influencing cure in cancer therapy.
作者信息
Bush R S, Jenkin R D, Allt W E, Beale F A, Bean H, Dembo A J, Pringle J F
出版信息
Br J Cancer Suppl. 1978 Jun;3:302-6.
Abstract
From an analysis of 2803 patients with carcinoma of the cervix treated by radiation therapy, a 62% cure rate can be shown. In those patients with Stage IIb and III disease, a haemoglobin level during treatment of below 12 g% was associated with a significantly higher pelvic recurrence rate, and also lower cure rate, than for those with a haemoglobin level 12g% or more. A prospective study shows that the correction of anaemia is associated with a decreased pelvic recurrence rate and an increased cure rate consistent with tumour hypoxia being greater in anaemic patients than in those with a normal haemoglobin level. It is also consistent with the thesis that hypoxia controls the radiation local control rate in patients with advanced carcinoma of the cervix.
摘要
对2803例接受放射治疗的宫颈癌患者进行分析后发现，治愈率可达62%。在IIb期和III期患者中，治疗期间血红蛋白水平低于12g%的患者盆腔复发率显著高于血红蛋白水平在12g%及以上的患者，治愈率也更低。一项前瞻性研究表明，纠正贫血与盆腔复发率降低和治愈率提高相关，这与贫血患者的肿瘤缺氧程度高于血红蛋白水平正常的患者一致。这也与缺氧控制晚期宫颈癌患者放射局部控制率的观点相符。
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