Hagstadius S, Orbaek P, Risberg J, Lindgren M
Department of Psychiatry I, University Hospital, Lund, Sweden.
Scand J Work Environ Health. 1989 Apr;15(2):130-5. doi: 10.5271/sjweh.1872.
Regional cerebral blood flow was measured in patients with the diagnosis of chronic toxic encephalopathy induced by exposure to organic solvents. Measurements were made at the time of diagnosis and 24-84 months after the cessation of exposure. During the follow-up the patients were carefully examined for other possible causes of brain dysfunction. Comparisons were made to unexposed and solvent-exposed referents. At the first examination the patients had a 7% lower mean flow level than the unexposed referents and a 5% lower level than the exposed workers. The largest flow differences were seen in the frontotemporal areas. At the follow-up, the difference in the mean flow level between the patients and referents was no longer significant. Regionally, the flow had increased, especially in areas which initially showed the most pronounced decreases. There was a significant negative correlation between the initial cerebral blood flow level and the degree of normalization of the flow level at follow-up.
对诊断为有机溶剂所致慢性中毒性脑病的患者进行了局部脑血流量测量。测量在诊断时以及停止接触后24至84个月进行。在随访期间，对患者进行了仔细检查，以寻找脑功能障碍的其他可能原因。与未接触者和接触溶剂的对照者进行了比较。在首次检查时，患者的平均血流水平比未接触者低7%，比接触溶剂的工人低5%。最大的血流差异出现在额颞叶区域。在随访时，患者与对照者之间的平均血流水平差异不再显著。从区域来看，血流有所增加，尤其是在最初血流下降最明显的区域。初始脑血流量水平与随访时血流水平的正常化程度之间存在显著的负相关。
