硝基吡咯放射增敏剂：结构与功能的关系
Nitropyrrole radiosensitizers: structure function relationships.
作者信息
Raleigh J A, Chapman J D, Reuvers A P, Biaglow J E, Durand R E, Rauth A M
出版信息
Br J Cancer Suppl. 1978 Jun;3:6-10.
Abstract
Nitropyrrole derivatives have been tested as hypoxic cell radiosensitizers in vitro and in vivo. Radiosensitizing potential generally increases with nitropyrrole electron affinity. N-hydroxyethyl substitution decreases toxicity relative to N--CH3, N--CH2 CH3 and N--CH2 CH2 CH3 substitution. The most effective nitropyrrole tested in vivo is N-hydroxyethyl-2-cyano-5-nitropyrrole (NP-1).
摘要
硝基吡咯衍生物已在体外和体内作为乏氧细胞放射增敏剂进行了测试。放射增敏潜力通常随硝基吡咯电子亲和力的增加而增强。相对于N-CH3、N-CH2 CH3和N-CH2 CH2 CH3取代，N-羟乙基取代降低了毒性。体内测试的最有效的硝基吡咯是N-羟乙基-2-氰基-5-硝基吡咯（NP-1）。
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本文引用的文献
1
HYDRATED ELECTRONS AND RADIOBIOLOGICAL SENSITISATION.水合电子与放射生物学增敏作用
Biochem Biophys Res Commun. 1963 Aug 20;12:473-7. doi: 10.1016/0006-291x(63)90318-8.
2
The effect on cell survival of inhalation of oxygen under high pressure during irradiation in vivo of a solid mouse sarcoma.在对实体小鼠肉瘤进行体内照射期间高压吸入氧气对细胞存活的影响。
Br J Radiol. 1966 Jan;39(457):19-24. doi: 10.1259/0007-1285-39-457-19.
3
Radiosensitization of mammalian cells by p-nitroacetophenone. I. Characterization in asynchronous and synchronous populations.
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19(6):561-73. doi: 10.1080/09553007114550741.
4
A lung-colony assay to determine the radiosensitivity of cells of a solid tumour.一种用于确定实体瘤细胞放射敏感性的肺集落测定法。
Int J Radiat Biol Relat Stud Phys Chem Med. 1969 Jul;15(5):435-44. doi: 10.1080/09553006914550721.
5
[Activity on Trichomonas vaginalis and other chemotherapeutic properties of 1-(2-hydroxyethyl)-2-carbamoyl-5-nitropyrrole (15,960 RP)].1-(2-羟乙基)-2-氨基甲酰基-5-硝基吡咯（15,960 RP）对阴道毛滴虫的活性及其他化疗特性
C R Acad Hebd Seances Acad Sci D. 1966 Aug 8;263(6):609-11.
6
Electron affinic sensitization. II. Para-nitroacetophenone: a radiosensitizer for anoxic bacterial and mammalian cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19(6):575-85. doi: 10.1080/09553007114550751.
7
Nitrofurans as radiosensitizers of hypoxic mammalian cells.硝基呋喃作为缺氧哺乳动物细胞的放射增敏剂。
Cancer Res. 1972 Dec;32(12):2616-24.
8
Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.信函：通过控制细胞呼吸对体外肿瘤模型辐射反应的修饰
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Dec;26(6):597-601. doi: 10.1080/09553007414551641.
9
Hypoxic cells in an in vitro tumour model.
Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Mar;23(3):235-46. doi: 10.1080/09553007314550261.
10
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