Durand R E, Biaglow J E, Greenstock C L
Br J Cancer Suppl. 1978 Jun;3:150-3.
Physiological factors are important when considering the effects of radiosensitizers on the radiation response of complex systems such as multicellular spheroids. In this system, under conditions of unlimited nutrient supply, cells are rendered hypoxic by metabolism. Thus, using the spheroid system as an in vitro model of the tumour-cell microenvironment, we have determined the relative contribution of radiosensitization and respiratory effects of a number of electron-affinic sensitizers having potential clinical use. These studies are indicative of physiological responses at the cellular level, and suggest optimal drug administration schemes for obtaining maximal radiation response in vivo hypoxic cell sensitizers.
在考虑放射增敏剂对诸如多细胞球体等复杂系统的辐射反应的影响时，生理因素很重要。在这个系统中，在营养供应不受限的条件下，细胞通过代谢而处于缺氧状态。因此，利用球体系统作为肿瘤细胞微环境的体外模型，我们已经确定了一些具有潜在临床应用价值的亲电子增敏剂的放射增敏作用和呼吸作用的相对贡献。这些研究表明了细胞水平的生理反应，并提出了在体内缺氧细胞增敏剂中获得最大辐射反应的最佳给药方案。
