Kalua Khumbo, Chisambi Alvin, Chinyanya David, Kamwendo Zachariah, Masika Michael, Willis Rebecca, Flueckiger Rebecca M, Pavluck Alexandre L, Solomon Anthony W
a Department of Ophthalmology , University of Malawi, College of Medicine , Blantyre , Malawi.
b Blantyre Institute for Community Ophthalmology , Lions Sight First Eye Hospital , Blantyre , Malawi.
Ophthalmic Epidemiol. 2016;23(sup1):32-38. doi: 10.1080/09286586.2016.1230224. Epub 2016 Oct 11.
Following a first phase of trachoma mapping in Malawi with the Global Trachoma Mapping Project, we identified and mapped trachoma districts previously suspected to be non-endemic, although adjacent to districts with estimated trachoma prevalences indicating a public health problem.
We conducted population-based surveys in eight evaluation units (EUs) comprising eight districts in Malawi (total population 3,230,272). A 2-stage cluster random sampling design allowed us to select 30 households from each of 30 clusters per EU; all residents aged 1 year and older in selected households were examined for evidence of trachomatous inflammation-follicular (TF) and trachomatous trichiasis (TT).
None of the eight EUs had a TF prevalence in 1-9-year-olds ≥10%, one district (Dedza) had a TF prevalence between 5.0% and 9.9%, and only one district (Karonga) had a trichiasis prevalence in adults ≥0.2%.
The prevalence of TF and TT in six of eight EUs surveyed was consistent with an original categorization of trachoma being unlikely to be a public health problem. In the absence of formal surveys, health management information system data and other locally available information about trachoma is likely to be useful in predicting areas where public health interventions against trachoma are required.
在马拉维开展全球沙眼地图绘制项目第一阶段的沙眼地图绘制工作后,我们识别并绘制了先前被怀疑为非流行区的沙眼地区,尽管这些地区与沙眼患病率估计表明存在公共卫生问题的地区相邻。
我们在马拉维8个区组成的8个评估单元(EU)中开展了基于人群的调查(总人口3,230,272)。两阶段整群随机抽样设计使我们能够从每个评估单元的30个整群中各选取30户家庭;对所选家庭中所有1岁及以上居民进行检查,以寻找滤泡性沙眼炎症(TF)和沙眼倒睫(TT)的证据。
8个评估单元中,没有一个单元1-9岁儿童的TF患病率≥10%,一个区(代扎)的TF患病率在5.0%至9.9%之间,只有一个区(卡龙加)成人的倒睫患病率≥0.2%。
在接受调查的8个评估单元中,有6个单元的TF和TT患病率与沙眼不太可能成为公共卫生问题的最初分类一致。在没有正式调查的情况下,卫生管理信息系统数据和其他当地可得的沙眼信息可能有助于预测需要开展沙眼公共卫生干预措施的地区。