Ertem Ahmet Goktug, Yayla Cagri, Acar Burak, Kirbas Ozgur, Unal Sefa, Uzel Sener Melahat, Akboga Mehmet Kadri, Efe Tolga Han, Sivri Serkan, Sen Fatih, Gokaslan Serkan, Topaloglu Serkan
Department of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Department of Chest Diseases, Ataturk Heart Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
Clin Respir J. 2018 Feb;12(2):580-586. doi: 10.1111/crj.12565. Epub 2016 Oct 20.
The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc).
We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE.
The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors.
LMR was significantly lower in non-survivors after APE (P < .001). Neutrophil-to-lymphocyte ratio (NLR) was higher in non-survivors after APE (P < .001). Platelet-to-lymphocyte (PLR) had no significance between both groups (P: .241). Simplified pulmonary embolism severity index and LMR were independent predictors of mortality in patients with APE (P: .008 and P: .001, respectively).
LMR as a novel marker of inflammation seemed to be an independent predictor of short-term mortality in patients with APE.
先前已使用不同变量（血小板/淋巴细胞比率等）研究了急性肺栓塞（APE）后炎症与死亡率之间的关系。
我们研究了淋巴细胞与单核细胞比率（LMR）对APE后30天内死亡率的预测价值。
研究人群包括264例APE患者，其中230例患者存活，34例患者未存活。
APE后未存活者的LMR显著较低（P <.001）。APE后未存活者的中性粒细胞与淋巴细胞比率（NLR）较高（P <.001）。两组之间血小板与淋巴细胞比率（PLR）无显著差异（P：.241）。简化肺栓塞严重程度指数和LMR是APE患者死亡率的独立预测因素（分别为P：.008和P：.001）。
LMR作为一种新的炎症标志物似乎是APE患者短期死亡率的独立预测因素。
