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颈动脉内膜切除术的近期及远期效果

Immediate and long-term results of carotid endarterectomy.

作者信息

Healy D A, Clowes A W, Zierler R E, Nicholls S C, Bergelin R O, Primozich J F, Strandness D E

机构信息

Department of Surgery, University of Washington School of Medicine, Seattle 98195.

出版信息

Stroke. 1989 Sep;20(9):1138-42. doi: 10.1161/01.str.20.9.1138.

Abstract

We review the long-term results of carotid endarterectomy in 200 consecutive patients operated on from 1980 to 1987. The patients were part of an ongoing study using duplex scanning to assess the status of the carotid bifurcation before and after endarterectomy. The average follow-up for the patients was 31 months. The indications for surgery were transient ischemic attacks in 87 (43.5%) and stroke in 36 (18%) patients; 77 patients (38.5%) were asymptomatic. In 176 sides (88%), the degree of stenosis exceeded 50% in terms of diameter reduction. The perioperative stroke rate was 2.3% in patients with transient ischemic attacks, 2.8% in patients with strokes, and 1.3% in asymptomatic patients. There was one perioperative death (0.5%). There were five occlusions of the internal carotid artery, one during the perioperative period and four after discharge; in three patients the occlusion was associated with the development of a stroke. There was a restenosis rate of 19.7% secondary to myointimal hyperplasia; such lesions did not appear to contribute to new ischemic events during or after their development. The mean stroke incidence after the decision was made for carotid endarterectomy was 2.8%/yr in the patients with transient ischemic attacks, 6.2%/yr in the patients with stroke, and 0.65%/yr in the asymptomatic patients. The annual death rate was 6% for the entire group, 5.5%/yr in the patients with transient ischemic attacks, 9.2%/yr in the patients with stroke, and 4.6%/yr in the asymptomatic patients.

摘要

我们回顾了1980年至1987年期间连续200例接受颈动脉内膜切除术患者的长期结果。这些患者是一项正在进行的研究的一部分,该研究使用双功扫描评估内膜切除术前和术后颈动脉分叉的状况。患者的平均随访时间为31个月。手术指征为:87例(43.5%)患者有短暂性脑缺血发作,36例(18%)患者有中风;77例(38.5%)患者无症状。176侧(88%)的狭窄程度按直径缩小计算超过50%。短暂性脑缺血发作患者的围手术期卒中率为2.3%,中风患者为2.8%,无症状患者为1.3%。有1例围手术期死亡(0.5%)。有5例颈内动脉闭塞,1例发生在围手术期,4例在出院后;3例患者的闭塞与中风的发生有关。继发于肌内膜增生的再狭窄率为19.7%;这些病变在发展过程中或发展后似乎并未导致新的缺血性事件。决定进行颈动脉内膜切除术后,短暂性脑缺血发作患者的平均卒中发生率为每年2.8%,中风患者为每年6.2%,无症状患者为每年0.65%。整个组的年死亡率为6%,短暂性脑缺血发作患者为每年5.5%,中风患者为每年9.2%,无症状患者为每年4.6%。

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