Humphries A W, Young J R, Santilli P H, Beven E G, deWolfe V G
Surgery. 1976 Dec;80(6):695-8.
One hundred and sixty-eight asymptomatic patients with a carotid artery stenosis of more than 50% were observed over a period of up to 12 years. During this time, 136 patients remained asymptomatic, two patients developed atypical neurologic symptoms that spontaneously disappeared, 26 patients developed transient ischemic attacks and successfully underwent carotid endarterectomy, three patients developed transient ischemic attacks that were ignored and they subsequently suffered a completed stroke, and one patient suffered a completed stroke without a warning transient attack. These data suggest that surgery is not required in the patient with an asymptomatic carotid stenosis until a transient ischemic attack occurs.
168例无症状性颈动脉狭窄超过50%的患者被观察了长达12年的时间。在此期间，136例患者仍无症状，2例患者出现非典型神经症状且自行消失，26例患者发生短暂性脑缺血发作并成功接受了颈动脉内膜切除术，3例患者发生短暂性脑缺血发作但未被重视，随后发生了完全性卒中，1例患者未出现先兆短暂发作而发生了完全性卒中。这些数据表明，无症状性颈动脉狭窄患者在发生短暂性脑缺血发作之前不需要进行手术。
