三甲基赖氨酸羟化酶催化的底物范围。
Substrate scope for trimethyllysine hydroxylase catalysis.
作者信息
Al Temimi Abbas H K, Pieters Bas J G E, Reddy Y Vijayendar, White Paul B, Mecinović Jasmin
机构信息
Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
出版信息
Chem Commun (Camb). 2016 Oct 25;52(87):12849-12852. doi: 10.1039/c6cc07845a.
Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(ii) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C-H bond in l-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogues as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural l-trimethyllysine.
三甲基赖氨酸羟化酶（TMLH）是一种非血红素铁（II）和2-氧代戊二酸依赖性加氧酶，在肉碱生物合成的第一步中催化L-三甲基赖氨酸中未活化的C-H键的C-3羟基化反应。对作为人TMLH底物的三甲基赖氨酸类似物的研究表明，该酶确实能使天然L-三甲基赖氨酸以外的底物发生羟基化反应。
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