人类肉碱的生物合成通过（2S，3S）-3-羟基-N-三甲基赖氨酸进行。

Leśniak Robert K, Markolovic Suzana, Tars Kaspars, Schofield Christopher J

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.

Biomedical Research and Study Centre, Ratsupites 1, LV1067 Riga, Latvia.

Chem Commun (Camb). 2016 Dec 22;53(2):440-442. doi: 10.1039/c6cc08381a.

N-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N-trimethyllysine.

N-三甲基赖氨酸羟化酶（TMLH）催化哺乳动物肉碱生物合成的第一步，肉碱在脂肪酸代谢中起关键作用。TMLH的3-羟基-N-三甲基赖氨酸产物的立体化学尚未确定。我们报告了酶促和不对称合成研究，这些研究将TMLH催化的产物定义为（2S，3S）-3-羟基-N-三甲基赖氨酸。