Wang Xin, Lamprou Alexandros, Svec Frantisek, Bai Yu, Liu Huwei
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China.
The Molecular Foundry, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
J Sep Sci. 2016 Dec;39(23):4544-4548. doi: 10.1002/jssc.201600810. Epub 2016 Nov 18.
A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal-organic framework for nano-liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4-vinylpyridine-co-ethylene dimethacrylate) column, excellent separations of both enantiomers of (±)-methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metal-organic framework [Zn (benzene dicarboxylate)(l-lactic acid)(dmf)], which is synthesized from zinc nitrate, l-lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.
已开发出一种制备用于纳米液相色谱的、包含手性金属有机骨架的对映选择性多孔聚合物整体柱的新方法。虽然聚（4-乙烯基吡啶-共-二甲基丙烯酸乙烯酯）整体柱未实现对映体分离，但在聚合混合物中由硝酸锌、L-乳酸和苯二甲酸合成的金属有机骨架[Zn（苯二甲酸）（L-乳酸）（二甲基甲酰胺）]与聚（4-乙烯基吡啶-共-二甲基丙烯酸乙烯酯）混合制备的整体柱实现了（±）-甲基苯基亚砜两种对映体的出色分离。这些新型整体柱将手性骨架的选择性与聚合物整体出色的流体动力学性质相结合，可能会对液相色谱手性分析领域的未来研究产生重大影响。
