用于手性药物对映体分离的环糊精功能化整体柱的最新进展。
Recent developments in cyclodextrin functionalized monolithic columns for the enantioseparation of chiral drugs.
作者信息
Guo Jialiang, Lin Yuanjing, Xiao Yuan, Crommen Jacques, Jiang Zhengjin
机构信息
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China.
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China; Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Liege, CHU B36, B-4000 Liege, Belgium.
出版信息
J Pharm Biomed Anal. 2016 Oct 25;130:110-125. doi: 10.1016/j.jpba.2016.05.023. Epub 2016 May 17.
The use of monolithic supports containing cyclodextrins (CDs) or their derivatives as chiral stationary phases (CSPs) has drawn much attention in the field of enantioseparations. The present review summarized the recent developments in CD functionalized monolithic columns. After introducing their classification in Section 1, various strategies applied to the preparation of the three types of CD functionalized monoliths, i.e. silica based monoliths, organic polymer based monoliths and organic-silica based hybrid monoliths, are thoroughly summarized in Section 2. Particularly, three different preparation strategies for covalently immobilizing CDs onto monoliths, including multi-step strategy, single-step strategy and one-pot strategy, are discussed. In the last section, the applications of CD functionalized monoliths in chiral separation of pharmaceuticals are highlighted.
使用含有环糊精（CDs）或其衍生物的整体式载体作为手性固定相（CSPs）在对映体分离领域引起了广泛关注。本综述总结了CD功能化整体柱的最新进展。在第1节介绍了它们的分类之后，第2节全面总结了应用于制备三种类型CD功能化整体柱的各种策略，即基于二氧化硅的整体柱、基于有机聚合物的整体柱和基于有机-二氧化硅的混合整体柱。特别讨论了将CD共价固定到整体柱上的三种不同制备策略，包括多步策略、单步策略和一锅法策略。在最后一节中，重点介绍了CD功能化整体柱在药物手性分离中的应用。
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