Wilsher Margaret L, Young Lisa M, Hopkins Raewyn, Cornere Megan
Respiratory Services, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand.
Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Respirology. 2017 Feb;22(2):360-363. doi: 10.1111/resp.12917. Epub 2016 Oct 12.
Ethnicity is strongly associated with variable clinical presentation in sarcoidosis but the association between ethnicity and clinical characteristics has not previously been described in patients of Polynesian ancestry, Maori and Pacific Islander (PI). The objective of this study was to describe the clinical characteristics of sarcoidosis in Maori and PI patients and determine if those were different to European patients.
A retrospective review of the medical records of 406 patients (69 Maori/PI) attending a specialist interstitial lung disease (ILD) clinic.
The population (207 females, mean age at presentation: 36) reflected the current New Zealand census data (2013) with only people of Indian ethnicity over-represented. Parenchymal lung involvement was uncommon in Maori and PI patients (21% Scadding stage 2, 2% stage 3), and no patient had extensive pulmonary fibrosis (stage 4). Computed tomography (CT) patterns of sarcoid parenchymal lung involvement were less commonly reported for Maori/PI. There were no differences in respect of baseline lung function or requirement for treatment. Ocular and skin involvement occurred more frequently in Maori and PI (P = 0.0045, P = 0.03), and erythema nodosum was more common in Caucasians (P = 0.0008).
People of Polynesian ancestry appear to have less pulmonary and more extra-pulmonary manifestations of sarcoidosis. This adds to our knowledge that sarcoidosis heterogeneity is influenced by ethnicity.
种族与结节病的临床表现差异密切相关，但此前尚未有关于毛利人和太平洋岛民（PI）这一波利尼西亚血统患者的种族与临床特征之间关联的描述。本研究的目的是描述毛利人和PI患者结节病的临床特征，并确定这些特征与欧洲患者是否不同。
对一家专科间质性肺病（ILD）诊所的406例患者（69例毛利人/PI）的病历进行回顾性研究。
该人群（207名女性，就诊时平均年龄：36岁）反映了当前新西兰人口普查数据（2013年），仅印度裔人群占比过高。毛利人和PI患者肺实质受累情况不常见（Scadding 2期占21%，3期占2%），且无患者出现广泛肺纤维化（4期）。毛利人/PI患者较少报告结节病肺实质受累的计算机断层扫描（CT）模式。在基线肺功能或治疗需求方面无差异。毛利人和PI患者眼部和皮肤受累更常见（P = 0.0045，P = 0.03），而结节性红斑在白种人中更常见（P = 0.0008）。
波利尼西亚血统人群的结节病肺部表现似乎较少，肺外表现较多。这进一步加深了我们对结节病异质性受种族影响的认识。
