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结核病与结节病的重叠:从诊断到治疗的临床挑战

Tuberculosis and Sarcoidosis Overlap: A Clinical Challenge From Diagnosis to Treatment.

作者信息

Pedroso Ana, Ferreira Inês, Chikura Teurai

机构信息

Internal Medicine Department, Hospital São Francisco Xavier, Lisboa, PRT.

Respiratory Medicine Department, Canterbury District Health Board, Christchurch, NZL.

出版信息

Cureus. 2020 Nov 23;12(11):e11662. doi: 10.7759/cureus.11662.

DOI:10.7759/cureus.11662
PMID:33391901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7769494/
Abstract

Tuberculosis (TB) and sarcoidosis have clinical, immunologic, and radiologic similarities and the differential diagnosis is often a challenge. Some cases are described in which patients have both diseases concomitantly. There is a hypothesis that posits TB and sarcoidosis as being along the spectrum of the same disease. This has important implications for treatment decisions, since immunosuppression, which is a treatment for sarcoidosis, is undesirable in TB patients. We are going to describe a clinical case of a TB patient who developed more severe symptoms during the course of TB treatment and, after excluding TB progression or resistance, he was diagnosed as probable sarcoidosis. He was started on immunosuppression, with great improvement, finishing the TB treatment completely asymptomatic.

摘要

结核病(TB)和结节病在临床、免疫和影像学方面存在相似之处,鉴别诊断往往具有挑战性。本文描述了一些患者同时患有这两种疾病的病例。有一种假说认为,结核病和结节病属于同一疾病谱。这对治疗决策具有重要意义,因为作为结节病治疗方法的免疫抑制,对结核病患者是不可取的。我们将描述一例结核病患者的临床病例,该患者在结核病治疗过程中出现了更严重的症状,在排除结核病进展或耐药后,被诊断为可能患有结节病。他开始接受免疫抑制治疗,病情有了很大改善,完成结核病治疗时完全没有症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c4/7769494/76817884be8c/cureus-0012-00000011662-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c4/7769494/7c0d0d50e12b/cureus-0012-00000011662-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c4/7769494/76817884be8c/cureus-0012-00000011662-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c4/7769494/7c0d0d50e12b/cureus-0012-00000011662-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c4/7769494/76817884be8c/cureus-0012-00000011662-i02.jpg

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本文引用的文献

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Characteristics of sarcoidosis in Maori and Pacific Islanders.毛利人和太平洋岛民结节病的特征。
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