Department of Pharmacology, University of California, San Diego, La Jolla, California 92093.
Department of Medicine, University of California, San Diego, La Jolla, California 92093.
Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:13-17. doi: 10.1146/annurev-pharmtox-091616-023708. Epub 2016 Oct 12.
Major advances in scientific discovery and insights can result from the development and use of new techniques, as exemplified by the work of Solomon Snyder, who writes a prefatory article in this volume. The Editors have chosen "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology" as the Theme for a number of articles in this volume. These include ones that review the development and use of new experimental tools and approaches (e.g., nanobodies and techniques to explore protein-protein interactions), new types of therapeutics (e.g., aptamers and antisense oligonucleotides), and systems pharmacology, which assembles (big) data derived from omics studies together with information regarding drugs and patients. The application of these new methods and therapeutic approaches has the potential to have a major impact on basic and clinical research in pharmacology and toxicology as well as on patient care.
重大的科学发现和见解的进步可以来自新技术的开发和应用，这方面的例子有 Solomon Snyder 的工作，他为本卷写了一篇前言文章。编辑们选择了“药理学和毒理学中的新方法和新治疗方法”作为本卷的一些文章的主题。这些文章包括回顾新实验工具和方法的开发和应用（例如纳米抗体和探索蛋白质-蛋白质相互作用的技术）、新型治疗方法（例如适体和反义寡核苷酸）以及系统药理学，它将来自组学研究的（大数据）与有关药物和患者的信息汇集在一起。这些新方法和治疗方法的应用有可能对药理学和毒理学的基础和临床研究以及患者护理产生重大影响。
