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代谢物蓄积与上皮间质转化：富马酸的转变。

Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate.

机构信息

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain.

出版信息

Cell Metab. 2016 Oct 11;24(4):529-530. doi: 10.1016/j.cmet.2016.09.020.

DOI:10.1016/j.cmet.2016.09.020
PMID:27732835
Abstract

Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.

摘要

癌细胞中克雷布斯循环酶琥珀酸水合酶的突变导致致癌代谢物琥珀酸的积累。Sciacovelli 等人（2016 年）证明，琥珀酸积累通过 miR-200 簇的表观遗传调控和 TET 去甲基化来介导上皮-间充质转化。

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