Kansal Anuraag R, Krotneva Stanimira, Tafazzoli Ali, Patel Harshali K, Borer Jeffrey S, Böhm Michael, Komajda Michel, Maya Juan, Tavazzi Luigi, Ford Ian, Kielhorn Adrian
a Evidera , Bethesda , MD , USA.
b Amgen Inc. , Thousand Oaks , CA , USA.
Curr Med Res Opin. 2017 Feb;33(2):185-191. doi: 10.1080/03007995.2016.1248381. Epub 2016 Oct 27.
The introduction of the Hospital Readmission Reduction Program (HRRP) has led to renewed interest in developing strategies to reduce 30 day readmissions among patients with heart failure (HF). In this study, a model was developed to investigate whether the addition of ivabradine to a standard-of-care (SoC) treatment regimen for patients with HF would reduce HRRP penalties incurred by a hypothetical hospital with excess 30 day readmissions.
A model using a Monte Carlo simulation framework was developed. Model inputs included national hospital characteristics, hospital-specific characteristics, and the ivabradine treatment effect as quantified by a post hoc analysis of the Systolic Heart failure treatment with the I inhibitor ivabradine Trial (SHIFT).
The model computed an 83% reduction in HF readmission penalty payments in a hypothetical hospital with a readmission rate of 22.95% (excess readmission ratio = 1.056 over the national average readmission rate of 21.73%), translating into net savings of $44,016. A sensitivity analysis indicated that the readmission penalty is affected by the specific characteristics of the hospital, including the readmission rate, size of the ivabradine-eligible population, and ivabradine utilization.
The results of this study indicate that the addition of ivabradine to an SoC treatment regimen for patients with HF may lead to a reduction in the penalties incurred by hospitals under the HRRP. This highlights the role ivabradine can play as part of a wider effort to optimize the care of patients with HF.
医院再入院率降低计划(HRRP)的推出引发了人们对制定策略以降低心力衰竭(HF)患者30天再入院率的新兴趣。在本研究中,开发了一个模型,以调查在HF患者的标准治疗(SoC)方案中添加伊伐布雷定是否会减少一家假设的30天再入院率过高的医院所面临的HRRP处罚。
开发了一个使用蒙特卡罗模拟框架的模型。模型输入包括全国医院特征、医院特定特征以及通过伊伐布雷定治疗收缩性心力衰竭试验(SHIFT)的事后分析量化的伊伐布雷定治疗效果。
该模型计算得出,一家再入院率为22.95%(再入院率比全国平均再入院率21.73%高出1.056)的假设医院的HF再入院处罚支付减少了83%,转化为净节省44,016美元。敏感性分析表明,再入院处罚受医院的特定特征影响,包括再入院率、符合使用伊伐布雷定条件的人群规模以及伊伐布雷定的使用情况。
本研究结果表明,在HF患者的SoC治疗方案中添加伊伐布雷定可能会减少医院在HRRP下所面临的处罚。这凸显了伊伐布雷定在优化HF患者护理的更广泛努力中可以发挥的作用。