Rawashdeh Oliver, Clough Shannon J, Hudson Randall L, Dubocovich Margarita L
Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
FASEB J. 2017 Jan;31(1):388-399. doi: 10.1096/fj.201600926R. Epub 2016 Oct 12.
The suprachiasmatic nucleus (SCN)-often referred to as the master circadian clock-is essential in generating physiologic rhythms and orchestrating synchrony among circadian clocks. This study tested the hypothesis that periodic motivation induced by rhythmically pairing 2 reinforcing stimuli [methamphetamine (Meth) and running wheel (RW)] restores autonomous circadian activity in arrhythmic SCN-lesioned (SCNX) C3H/HeN mice. Sham-surgery and SCNX mice were treated with either Meth (1.2 mg/kg, i.p.) or vehicle in association, dissociation, or absence of an RW. Only the association of Meth treatment and restricted RW access successfully reestablished entrained circadian rhythms in mice with SCNX. RW-likely acting as a link between the circadian and reward systems-promotes circadian entrainment of activity. We conclude that a conditioned drug response is a powerful tool to entrain, drive, and restore circadian physiology. Furthermore, an RW should be recognized as a potent input signal in addition to the conventional use as an output signal.-Rawashdeh, O., Clough, S. J., Hudson, R. L., Dubocovich, M. L. Learned motivation drives circadian physiology in the absence of the master circadian clock.
视交叉上核（SCN）——常被称为主生物钟——对于产生生理节律以及协调生物钟之间的同步至关重要。本研究检验了以下假设：通过有节律地配对两种强化刺激物[甲基苯丙胺（Meth）和跑步轮（RW）]诱导的周期性动机可恢复无节律的SCN损伤（SCNX）C3H/HeN小鼠的自主昼夜活动。假手术和SCNX小鼠在有RW、无RW或RW分离的情况下，分别接受Meth（1.2mg/kg，腹腔注射）或溶剂处理。只有Meth处理与限制使用RW相结合，才能成功地在SCNX小鼠中重新建立昼夜节律。RW可能作为昼夜节律和奖赏系统之间的联系，促进活动的昼夜节律性调整。我们得出结论，条件性药物反应是一种强大的工具，可用于调整、驱动和恢复昼夜生理功能。此外，除了作为传统的输出信号外，RW还应被视为一种强大的输入信号。——拉瓦什德，O.，克拉夫，S.J.，哈德森，R.L.，杜博科维奇，M.L.在没有主生物钟的情况下，习得性动机驱动昼夜生理功能。
