Ding Wuxiao, Aoyagi Masaru, Masuda Mitsutoshi, Kogiso Masaki
Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST).
J Oleo Sci. 2016 Dec 1;65(12):1011-1016. doi: 10.5650/jos.ess16132. Epub 2016 Oct 12.
A novel lipid nanocapsule with high physical stability and the ability to undergo a water-responsive morphological change was prepared using a facile method from inexpensive and simple materials such as a glycylglycine-containing lipid and zinc acetate. The zinc-coordinated nanocapsule is comprised of solid bilayer membranes, which are stabilized by polyglycine-II type hydrogen-bond network and Zn-lipid coordination resulting in a high thermal stability in the dry state. The nanocapsules can easily encapsulate guest molecules such as methylene blue in the hollow space by dissolving the molecules in ethanol during preparation. When placed in an aqueous environment, the nanocapsules showed distinctive morphological changes and subsequent release of the methylene blue.
采用简便方法，以含甘氨酰甘氨酸的脂质和醋酸锌等廉价且简单的材料制备了一种具有高物理稳定性且能发生水响应形态变化的新型脂质纳米胶囊。锌配位纳米胶囊由固体双层膜组成，该双层膜通过聚甘氨酸-II型氢键网络和锌-脂质配位作用得以稳定，从而在干燥状态下具有高热稳定性。在制备过程中，通过将诸如亚甲蓝等客体分子溶解于乙醇中，纳米胶囊能够轻松地将其包裹在中空空间内。当置于水性环境中时，纳米胶囊呈现出独特的形态变化，并随后释放出亚甲蓝。
