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[研究磷脂在甲状腺功能减退症诊断中的意义]

[The significance of studying phospholipids in the diagnosis of hypothyroidism].

作者信息

Zelinskaia N B

出版信息

Vrach Delo. 1989 May(5):79-81.

PMID:2773445
Abstract

Phospholipids and their fractions were examined in 85 patients with hypothyroidism of various severity grades in the state of decompensation. It was established that hypothyroidism is characterized by essential disorders of the phospholipid metabolism which occurs already at the initial stages of the disease advances with progression of its severity and is manifested in an increase of phosphatidylserine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine and reduction of phosphatidylcholine. Examination of phospholipids and their fractions is one of the important supplementary objective methods of diagnosis of hypothyroidism, especially, in young persons, a criterion of metabolic decompensation of the disease.

摘要

对85例失代偿期不同严重程度等级的甲状腺功能减退症患者的磷脂及其组分进行了检查。结果表明,甲状腺功能减退症的特征是磷脂代谢存在本质性紊乱,这种紊乱在疾病初期就已出现,并随着病情严重程度的进展而加重,表现为磷脂酰丝氨酸、溶血磷脂酰胆碱、鞘磷脂、磷脂酰乙醇胺增加,磷脂酰胆碱减少。磷脂及其组分的检查是诊断甲状腺功能减退症的重要辅助客观方法之一,尤其是在年轻人中,是该疾病代谢失代偿的一个标准。

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