Koleva T, Malcheva I
Vutr Boles. 1989;28(3):90-6.
The study is based on the statistical data of 3317 hospitalized patients 310 of whom (9.34%) were hospitalized because of a drug untoward reaction. The drug side effects are more frequent in women (60.64%) than in men (39.35%). The most affected age groups are those of 20-29 and 30-39 years. 74.21% of the untoward reactions are of immune character and the remaining are pharmacologic. The greater part of the untoward reactions are due to the following drugs: noramidopyrine (10.4%), co-trimoxazole (9.07%), acetylsal (8.21%) and amoxycillin (6.23%). Most frequently affected are: the skin (44.41%), the central and peripheral nervous system (17.41%) and the cardiovascular system (11.06%).
该研究基于3317名住院患者的统计数据，其中310名（9.34%）因药物不良反应而住院。药物副作用在女性（60.64%）中比在男性（39.35%）中更常见。受影响最严重的年龄组是20 - 29岁和30 - 39岁。74.21%的不良反应具有免疫性质，其余为药理性质。大部分不良反应是由以下药物引起的：氨基比林（10.4%）、复方新诺明（9.07%）、阿司匹林（8.21%）和阿莫西林（6.23%）。受影响最频繁的是：皮肤（44.41%）、中枢和周围神经系统（17.41%）以及心血管系统（11.06%）。
