Ludin H P
Klinik für Neurologie, Kantonsspital St. Gallen.
Ther Umsch. 1993 Jan;50(1):23-7.
ADRs presenting as neurologic or psychic disturbances are rather frequent; therefore, it will not be possible to give a complete overview. Drug-induced extrapyramidal syndromes which are due to an interference of the drug or a drug metabolite with cerebral dopaminergic mechanisms in most instances are discussed in more detail. Neuroleptics are prominent in this group of preparations. Drug-induced Parkinsonism, acute dystonia, tardive dyskinesia and the neuroleptic malignant syndrome are the ADRs presented herein.
表现为神经或精神障碍的不良反应相当常见;因此,无法给出完整的概述。本文将更详细地讨论大多数情况下由药物或药物代谢物干扰大脑多巴胺能机制引起的药物性锥体外系综合征。在这类制剂中,抗精神病药物最为突出。本文介绍的不良反应包括药物性帕金森症、急性肌张力障碍、迟发性运动障碍和抗精神病药物恶性综合征。