Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China.
Molecular Hepatology-Alcohol Associated Diseases, II. Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Sci Rep. 2016 Oct 13;6:35389. doi: 10.1038/srep35389.
Magnetic resonance cholangiopancreatography (MRCP), MRCP after secretin stimulation (S-MRCP) and endoscopic ultrasonography (EUS) are all selected to diagnose pancreas divisum. However, the accuracies of three diagnosis remain unclear. The aim is to address the diagnostic accuracies of MRCP, S-MRCP and EUS on pancreas divisum. We searched PubMed, MEDLINE and EMBASE databases from inception to January, 2015. Of the 536 citations retrieved, 16 studies were included. For MRCP diagnosis on pancreas divisum, the area under the hierarchical summary receiver-operating characteristic (HSROC) curve was 0.90 (95% confidence interval [CI] 0.87 to 0.92), and for S-MRCP and EUS, 0.99 (95% CI 0.97 to 0.99) and 0.97 (95% CI 0.96 to 0.98). Sensitivity and specificity for MRCP were 0.59 (95% CI 0.45 to 0.71) and 0.99 (95% CI 0.96 to 1.00); for S-MRCP, 0.83 (95% CI 0.66 to 0.92) and 0.99 (95% CI 0.96 to 1.00); for EUS, 0.85 (95% CI 0.67 to 0.94) and 0.97 (95% CI 0.90 to 0.99). Comprehensive comparison of three diagnostic techniques to pancreas divisum, S-MRCP was more reliable than MRCP and EUS on the effect of the diagnostic test.
磁共振胆胰管成像（MRCP）、促胰液素刺激后的 MRCP（S-MRCP）和内镜超声检查（EUS）均被用于诊断胰腺分裂症。然而，三种诊断方法的准确性尚不清楚。本研究旨在评估 MRCP、S-MRCP 和 EUS 对胰腺分裂症的诊断准确性。我们检索了从建库至 2015 年 1 月的 PubMed、MEDLINE 和 EMBASE 数据库。从 536 条引文中共纳入了 16 项研究。MRCP 诊断胰腺分裂症的综合受试者工作特征（HSROC）曲线下面积为 0.90（95%置信区间 [CI] 0.87 至 0.92），S-MRCP 和 EUS 的曲线下面积分别为 0.99（95% CI 0.97 至 0.99）和 0.97（95% CI 0.96 至 0.98）。MRCP 的敏感度和特异度分别为 0.59（95% CI 0.45 至 0.71）和 0.99（95% CI 0.96 至 1.00）；S-MRCP 为 0.83（95% CI 0.66 至 0.92）和 0.99（95% CI 0.96 至 1.00）；EUS 为 0.85（95% CI 0.67 至 0.94）和 0.97（95% CI 0.90 至 0.99）。综合比较三种诊断技术，S-MRCP 对胰腺分裂症的诊断效果优于 MRCP 和 EUS。
