Ravikumar Vinod K, Ho Allen L, Parker Jonathon J, Erickson-DiRenzo Elizabeth, Halpern Casey H
Department of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA.
Brain Sci. 2016 Oct 10;6(4):48. doi: 10.3390/brainsci6040048.
Tremulous voice is characteristically associated with essential tremor, and is referred to as essential vocal tremor (EVT). Current estimates suggest that up to 40% of individuals diagnosed with essential tremor also present with EVT, which is associated with an impaired quality of life. Traditional EVT treatments have demonstrated limited success in long-term management of symptoms. However, voice tremor has been noted to decrease in patients receiving deep brain stimulation (DBS) with the targeting of thalamic nuclei. In this study, we describe our multidisciplinary procedure for awake, frameless DBS with optimal stimulation targets as well as acoustic analysis and laryngoscopic assessment to quantify tremor reduction. Finally, we investigate the most recent clinical evidence regarding the procedure.
震颤性嗓音典型地与特发性震颤相关，被称为特发性嗓音震颤（EVT）。目前的估计表明，高达40%被诊断为特发性震颤的个体也伴有EVT，这与生活质量受损有关。传统的EVT治疗在症状的长期管理方面成效有限。然而，已注意到接受丘脑核团靶向性脑深部电刺激（DBS）的患者其嗓音震颤有所减轻。在本研究中，我们描述了我们针对清醒、无框架DBS的多学科手术方法，包括最佳刺激靶点以及用于量化震颤减轻情况的声学分析和喉镜评估。最后，我们调查了有关该手术的最新临床证据。
