Moyanova S, Dimov S, Popivanov D
Institute of Physiology, Bulgarian Academy of Sciences.
Acta Physiol Pharmacol Bulg. 1989;15(1):47-53.
The effect of DL-allylglycine (DL-AG) in two doses (40 and 60 mg/kg i.v.) was studied on cats under acute conditions. DL-AG provoked the appearance of epileptiform EEG patterns either spontaneous or in response to intermittent light stimulation with a frequency of 5-25 Hz. The effect was dose-dependent. The paroxysmal EEG was restricted to or began in the cortex and later it appeared in the thalamus and mesencephalic reticular formation. This finding together with the observation that after DL-AG the visual evoked potentials increased in the primary visual cortex and decreased in the centre median nucleus and in the reticular formation support the view about the role of the cortex in the increased brain excitability and in the increased photosensitivity after allylglycine. The photosensitive of spontaneous epileptiform EEG activity in cats pretreated with DL-allylglycine could be an useful experimental model of epilepsy for assessing the efficacy of anticonvulsant drugs.
在急性条件下，研究了两种剂量（40和60毫克/千克静脉注射）的DL-烯丙基甘氨酸（DL-AG）对猫的影响。DL-AG引发了癫痫样脑电图模式的出现，这些模式要么是自发的，要么是对频率为5-25赫兹的间歇性光刺激的反应。这种影响是剂量依赖性的。阵发性脑电图局限于皮质或始于皮质，随后出现在丘脑和中脑网状结构。这一发现，连同观察到在给予DL-AG后，初级视觉皮质中的视觉诱发电位增加，而在中央中核和网状结构中则减少，支持了关于皮质在烯丙基甘氨酸后大脑兴奋性增加和光敏性增加中所起作用的观点。用DL-烯丙基甘氨酸预处理的猫中自发癫痫样脑电图活动的光敏性，可能是用于评估抗惊厥药物疗效的有用癫痫实验模型。
