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肩关节置换术后有症状静脉血栓栓塞的发生率及危险因素

Incidence of and Risk Factors for Symptomatic Venous Thromboembolism After Shoulder Arthroplasty.

作者信息

Tashjian Robert Z, Lilly Daniel T, Isaacson Aaron M, Georgopoulos Cory E, Bettwieser Stephen P, Burks Robert T, Greis Patrick E, Presson Angela P, Granger Erin K, Zhang Yue

机构信息

Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT.

出版信息

Am J Orthop (Belle Mead NJ). 2016 Sep/Oct;45(6):E379-E385.

Abstract

Reported rates of venous thromboembolism (VTE) after shoulder arthroplasty (SA) range from 0.2% to 13%. Few studies have evaluated the incidence of VTE in a large patient population from a single institution. We conducted a study to determine the incidence of VTE (deep venous thrombosis [DVT] and pulmonary embolism [PE]) in a large series of SAs. Cases of SAs performed at our institution between January 1999 and May 2012 were retrospectively reviewed for development of symptomatic VTE within the first 90 days after surgery. During the study period, 533 SAs (245 anatomical total SAs [TSAs], 112 reverse TSAs, 92 hemiarthroplasties, 84 revision SAs) were performed. Logistic regression analyses were used to evaluate the association of various risk factors with VTE. For the 533 SAs, the symptomatic VTE rate was 2.6% (14 patients), the DVT rate was 0.9% (5), and the PE rate was 2.3% (12). Risk factors significantly correlated with a thrombotic event included raised Charlson Comorbidity Index, preoperative thrombotic event, lower preoperative hemoglobin and hematocrit levels, diabetes, lower postoperative hemoglobin level, use of general endotracheal anesthesia without interscalene nerve block, higher body mass index, and revision SA (P < .05). Our rates of symptomatic VTE events (DVT, PE) after SA are relatively low, though they are higher than the rates in studies that have used large state or national databases. Risk factors associated with thrombosis can be useful in identifying patients at risk for clotting after SA.

摘要

肩关节置换术(SA)后报告的静脉血栓栓塞症(VTE)发生率在0.2%至13%之间。很少有研究在来自单一机构的大量患者群体中评估VTE的发生率。我们进行了一项研究,以确定大量SA患者中VTE(深静脉血栓形成[DVT]和肺栓塞[PE])的发生率。对1999年1月至2012年5月在我们机构进行的SA病例进行回顾性分析,以确定术后90天内出现症状性VTE的情况。在研究期间,共进行了533例SA手术(245例解剖型全肩关节置换术[TSA]、112例反式TSA、92例半肩关节置换术、84例翻修SA)。采用逻辑回归分析评估各种风险因素与VTE的相关性。对于这533例SA患者,症状性VTE发生率为2.6%(14例患者),DVT发生率为0.9%(5例),PE发生率为2.3%(12例)。与血栓形成事件显著相关的风险因素包括Charlson合并症指数升高、术前血栓形成事件、术前血红蛋白和血细胞比容水平较低、糖尿病、术后血红蛋白水平较低、使用全身气管内麻醉且未行肌间沟神经阻滞、较高的体重指数以及翻修SA(P<0.05)。我们的SA术后症状性VTE事件(DVT、PE)发生率相对较低,尽管高于使用大型州或国家数据库的研究中的发生率。与血栓形成相关的风险因素有助于识别SA术后有凝血风险的患者。

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