Gohy Sophie, Froidure Antoine, Lebecque Patrick
Department of Pulmonology, Cliniques Universitaires St-Luc, Avenue Hippocrate 10, B-1200 Brussels, Belgium.
Pediatric Pulmonology and Cystic Fibrosis Unit, Cliniques Universitaires St-Luc, Avenue Hippocrate 10, B-1200 Brussels, Belgium.
Pediatr Pulmonol. 2017 Apr;52(4):E18-E21. doi: 10.1002/ppul.23567. Epub 2016 Oct 14.
Drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a rare and severe side-effect, mainly described after intake of anticonvulsants, allopurinol, or antibiotics. It usually begins within 2 months after drug introduction. Symptoms include cutaneous rash, hematologic abnormalities, and internal organ involvement and the diagnosis might be challenging. This case report illustrates for the first time this life-threatening complication in a patient with cystic fibrosis (CF). In this case, withdrawal of the offending drug was sufficient for full recovery. Clinicians involved in CF care should be aware of DRESS syndrome, as they commonly prescribe several potentially culprit drugs. Pediatr Pulmonol. 2017;52:E18-E21. © 2016 Wiley Periodicals, Inc.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征是一种罕见且严重的副作用，主要在服用抗惊厥药、别嘌醇或抗生素后出现。它通常在用药后2个月内开始。症状包括皮疹、血液学异常和内脏器官受累，诊断可能具有挑战性。本病例报告首次阐述了一名囊性纤维化（CF）患者出现的这种危及生命的并发症。在该病例中，停用致病药物足以实现完全康复。参与CF护理的临床医生应了解DRESS综合征，因为他们通常会开具几种可能的致病药物。《儿科肺科杂志》。2017年；52：E18 - E21。©2016威利期刊公司。
