Sarajärvi Piia, Kubin Minna, Tasanen Kaisa, Huilaja Laura
Duodecim. 2017;133(1):43-51.
DRESS (drug reaction with eosinophilia and systemic symptoms) is a rare, severe multiorgan adverse drug reaction. Antiepileptic age's and antibiotics are the most frequently reported causative agents. Compared with other drug reactions, DRESS demonstrates a long latency period thus complicating recognition and diagnosis. DRESS is defined as presence of fever, skin eruption, hematologic abnormalities and systemic involvement, especially liver injury. Withdrawal of the culprit drug, commencement of systemic corticosteroid and supportive care are the mainstay of treatment. The majority of patients recover completely after drug withdrawal and appropriate therapy. Some patients suffer from chronic sequelae or even death.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种罕见的严重多器官药物不良反应。抗癫痫药物和抗生素是最常报告的致病因素。与其他药物反应相比，DRESS的潜伏期较长，因此识别和诊断较为复杂。DRESS的定义为发热、皮疹、血液学异常和全身受累，尤其是肝损伤。停用致病药物、开始全身使用糖皮质激素和支持治疗是主要的治疗方法。大多数患者在停药和适当治疗后可完全康复。一些患者会出现慢性后遗症甚至死亡。
