Fu Xi, Lindgren Torsten, Wieslander Gunilla, Janson Christer, Norbäck Dan
Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, University Hospital, Uppsala, Sweden.
Respiratory, Allergy and Sleep Research, Department of Medical Sciences, Uppsala University, University Hospital, Uppsala, Sweden.
PLoS One. 2016 Oct 14;11(10):e0164954. doi: 10.1371/journal.pone.0164954. eCollection 2016.
The aim was to study associations between work and home environment and prevalence and incidence of respiratory health and a history of atopy in a 3-y cohort of commercial pilots. A questionnaire was mailed in 1997 to all pilots in a Scandinavian airline company (N = 622); 577 (93%) participated. The same questionnaire was sent to the participants 3 years later, 436 participated (76%). There were questions on asthma, respiratory symptoms and infections, allergies, the cabin environment, psychosocial environment and the home environment. Associations were analyzed by multiple logistic regression, calculating odds ratios (OR) with 95% confidence intervals (95%CI). The incidence of doctors' diagnosed asthma and atopy were 2.4 and 16.6 per 1000 person years, respectively. Pilots changing type of flight during follow-up got more airway infections (OR = 11.27; 95% CI 2.39-53.14). Those reporting decreased work control (OR = 1.85; 95% CI 1.03-3.31 for 1 unit change) and those with environmental tobacco smoke (ETS) at home (OR = 3.73; 95% CI 1.09-12.83) had a higher incidence of atopy during follow up. Dampness or mould at home was associated with a higher prevalence of asthma symptoms (OR = 3.55; 95% CI 1.43-8.82) and airway infections (OR = 3.12 95% CI 1.27-7.68). Window pane condensation in winter at home, reported at baseline, was associated with increased incidence of asthma symptoms (OR = 4.14; 95% CI 1.32-12.97) and pilots living in newer buildings at baseline had a higher incidence of airway infections (OR = 5.23; 95% CI 1.43-19.10). In conclusion, lack of work control and ETS at home can be a risk factors for development of allergic symptoms in pilots. Window pane condensation at home can be a risk factor for incidence of asthma symptoms. Dampness and mould at home can be a risk factor for prevalence of asthma symptoms and airway infections and living in newer buildings can be a risk factor for incidence of airway infections.
目的是研究在一个为期3年的商业飞行员队列中,工作和家庭环境与呼吸道健康患病率、发病率以及特应性病史之间的关联。1997年,向一家斯堪的纳维亚航空公司的所有飞行员(N = 622)邮寄了一份问卷;577人(93%)参与。3年后,向参与者发送了相同的问卷,436人参与(76%)。问卷内容涉及哮喘、呼吸道症状与感染、过敏、机舱环境、心理社会环境和家庭环境。通过多元逻辑回归分析关联,计算比值比(OR)及95%置信区间(95%CI)。医生诊断的哮喘和特应性发病率分别为每1000人年2.4例和16.6例。随访期间更换飞行类型的飞行员呼吸道感染更多(OR = 11.27;95% CI 2.39 - 53.14)。报告工作控制感降低的人(每单位变化的OR = 1.85;95% CI 1.03 - 3.31)以及家中有环境烟草烟雾(ETS)的人(OR = 3.73;95% CI 1.09 - 12.83)在随访期间特应性发病率更高。家中潮湿或有霉菌与哮喘症状的较高患病率(OR = 3.55;95% CI 1.43 - 8.82)和呼吸道感染(OR = 3.12,95% CI 1.27 - 7.68)相关。在基线时报告家中冬季窗玻璃有凝结现象与哮喘症状发病率增加相关(OR = 4.14;95% CI 1.32 - 12.97),且基线时居住在较新建筑中的飞行员呼吸道感染发病率更高(OR = 5.23;95% CI 1.43 - 19.10)。总之,工作控制感缺失和家中的环境烟草烟雾可能是飞行员出现过敏症状的危险因素。家中窗玻璃凝结现象可能是哮喘症状发病率的危险因素。家中潮湿和霉菌可能是哮喘症状患病率和呼吸道感染的危险因素,而居住在较新建筑中可能是呼吸道感染发病率的危险因素。