探究脑癌中的代谢情况。
Interrogating Metabolism in Brain Cancer.
作者信息
Salzillo Travis C, Hu Jingzhe, Nguyen Linda, Whiting Nicholas, Lee Jaehyuk, Weygand Joseph, Dutta Prasanta, Pudakalakatti Shivanand, Millward Niki Zacharias, Gammon Seth T, Lang Frederick F, Heimberger Amy B, Bhattacharya Pratip K
机构信息
Department of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, TX, USA.
出版信息
Magn Reson Imaging Clin N Am. 2016 Nov;24(4):687-703. doi: 10.1016/j.mric.2016.07.003.
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.
本文综述了用于探究脑癌代谢的现有技术和新兴技术，从成熟的质子磁共振波谱技术到前景广阔的超极化代谢成像和化学交换饱和转移技术，以及新兴的炎症成像技术。其中一些技术尚处于开发初期，针对患者的临床试验正在进行中，以确定其临床疗效。体内代谢组学和代谢成像很可能是脑癌诊断和评估治疗效果的下一个前沿领域；结合基因组学和蛋白质组学知识，或许能够全面了解脑肿瘤的发生机制。
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