Flori Alessandra, Liserani Matteo, Bowen Sean, Ardenkjaer-Larsen Jan Henrik, Menichetti Luca
Fondazione CNR/Regione Toscana G. Monasterio, Pisa, I-56124, Italy.
J Phys Chem A. 2015 Mar 12;119(10):1885-93. doi: 10.1021/jp511972g. Epub 2015 Mar 2.
The intrinsic physicochemical properties of the sample formulation are the key factors for efficient hyperpolarization through dissolution dynamic nuclear polarization (dissolution-DNP). We provide a comprehensive characterization of the DNP process for Na-[1-(13)C]acetate selected as a model for non-self-glassing agents: the solid-state polarization dynamics of different formulations and the effect of the paramagnetic agent (trityl radical) on the pattern of polarization and the relaxation profile were extensively analyzed. We quantified the effects of the glassing agent and Gd(3+)-chelate on DNP performance. The results reported here describe the constraints of the acetate formulation useful for future studies in this field with non-self-glassing enriched molecules.
样品制剂的固有物理化学性质是通过溶解动态核极化（溶解 - DNP）实现高效超极化的关键因素。我们对选择作为非自玻璃化剂模型的Na - [1 - (13)C]乙酸盐的DNP过程进行了全面表征：广泛分析了不同制剂的固态极化动力学以及顺磁剂（三苯甲基自由基）对极化模式和弛豫曲线的影响。我们量化了玻璃化剂和Gd(3 +) - 螯合物对DNP性能的影响。此处报道的结果描述了乙酸盐制剂的限制条件，这对该领域未来使用非自玻璃化富集分子的研究很有用。
