Vezeteu Thomas V, Bobiş Otilia, Moritz Robin F A, Buttstedt Anja
Institut für Biologie, Zoologie - Molekulare Ökologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany.
Departamentul de Apiculturǎ şi Sericiculturǎ, Facultatea de Zootehnie şi Biotehnologii, Universitatea de Ştiinţe Agricole şi Medicinǎ Veterinarǎ, Cluj-Napoca, Romania.
Microbiologyopen. 2017 Feb;6(1). doi: 10.1002/mbo3.397. Epub 2016 Oct 14.
Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval food jelly contains antibiotic compounds. However, although food jelly is primarily consumed by bee larvae, studies investigating the antibiotic effects of this jelly have largely concentrated on bacterial human diseases. In this study, we show that royal jelly fed to queen larvae and added to the jelly of drone and worker larvae, inhibits not only the growth of European Foulbrood-associated bacteria but also its causative agent M. plutonius. This effect is shown to be caused by the main protein (major royal jelly protein 1) of royal jelly.
蜜蜂蜂群（西方蜜蜂）为各种病原体提供了适宜的温度、湿度和丰富的食物，是极具吸引力的宿主。因此，蜜蜂一生都要应对病原体，即使在幼虫阶段，它们也会受到严重的幼虫疾病影响，比如由蜂房蜜蜂球菌引起的欧洲幼虫腐臭病。相应地，幼虫食用的蜂粮含有抗生素化合物具有高度适应性。然而，尽管蜂粮主要由蜜蜂幼虫食用，但研究这种蜂粮抗生素作用的研究主要集中在人类细菌性疾病上。在本研究中，我们发现喂给蜂王幼虫以及添加到雄蜂和工蜂幼虫蜂粮中的蜂王浆，不仅能抑制与欧洲幼虫腐臭病相关细菌的生长，还能抑制其病原体蜂房蜜蜂球菌的生长。这种作用被证明是由蜂王浆的主要蛋白质（主要蜂王浆蛋白1）引起的。
