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Simulated microgravity inhibits the migration of mesenchymal stem cells by remodeling actin cytoskeleton and increasing cell stiffness.模拟微重力通过重塑肌动蛋白细胞骨架和增加细胞硬度来抑制间充质干细胞的迁移。
Cytotechnology. 2016 Dec;68(6):2235-2243. doi: 10.1007/s10616-016-0007-x. Epub 2016 Oct 15.
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Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation.模拟微重力通过使丝状肌动蛋白解聚以阻碍转录共激活因子TAZ的核转位，从而抑制间充质干细胞的成骨分化。
Sci Rep. 2016 Jul 22;6:30322. doi: 10.1038/srep30322.
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Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells through down regulating the transcriptional co-activator TAZ.模拟微重力通过下调转录共激活因子TAZ抑制间充质干细胞的成骨分化。
Biochem Biophys Res Commun. 2015;468(1-2):21-6. doi: 10.1016/j.bbrc.2015.11.006. Epub 2015 Nov 6.
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The simulated microgravity enhances multipotential differentiation capacity of bone marrow mesenchymal stem cells.模拟微重力增强骨髓间充质干细胞的多向分化能力。
Cytotechnology. 2014 Jan;66(1):119-31. doi: 10.1007/s10616-013-9544-8. Epub 2013 Apr 12.
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Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway.模拟微重力通过抑制 ERK/β-连环蛋白信号通路抑制鼠真皮成纤维细胞间充质干细胞的分化。
Int J Mol Sci. 2021 Oct 2;22(19):10702. doi: 10.3390/ijms221910702.
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Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F-actin/YAP signaling pathway.模拟微重力通过 F-肌动蛋白/YAP 信号通路抑制真皮成纤维细胞迁移，从而减弱皮肤伤口愈合。
J Cell Physiol. 2023 Dec;238(12):2751-2764. doi: 10.1002/jcp.31126. Epub 2023 Oct 5.
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Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity.在模拟微重力条件下，肌动蛋白细胞骨架通过前成骨细胞中的钙调蛋白1介导骨形态发生蛋白2- Smad信号传导。
Biochimie. 2017 Jul;138:184-193. doi: 10.1016/j.biochi.2017.04.015. Epub 2017 Apr 27.
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Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cells.模拟微重力对人骨髓间充质干细胞成骨分化过程中 RNA 表达谱的影响。
Cell Prolif. 2019 Mar;52(2):e12539. doi: 10.1111/cpr.12539. Epub 2018 Nov 5.
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Simulated microgravity reduces proliferation and reorganizes the cytoskeleton of human umbilical cord mesenchymal stem cells.模拟微重力会减少人脐带间充质干细胞的增殖并重组其细胞骨架。
Physiol Res. 2020 Nov 16;69(5):897-906. doi: 10.33549/physiolres.934472. Epub 2020 Sep 9.
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Alterations in Nuclear Lamina and the Cytoskeleton of Bone Marrow-Derived Human Mesenchymal Stem Cells Cultured Under Simulated Microgravity Conditions.模拟微重力条件下培养的骨髓间充质干细胞的核层和细胞骨架的改变。
Stem Cells Dev. 2019 Sep 1;28(17):1167-1176. doi: 10.1089/scd.2018.0229. Epub 2019 Jul 17.
引用本文的文献
1
Aging and Altered Gravity: A Cellular Perspective.衰老与重力改变：细胞层面的视角
FASEB J. 2025 Jul 15;39(13):e70777. doi: 10.1096/fj.202402989R.
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Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.来自太空人类干细胞研究的发现，这些发现与推进地球上的细胞疗法相关。
NPJ Microgravity. 2024 Aug 21;10(1):88. doi: 10.1038/s41526-024-00425-0.
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Osteogenesis of bone marrow mesenchymal stem cell in hyperglycemia.高血糖症下骨髓间充质干细胞的成骨作用。
Front Endocrinol (Lausanne). 2023 Jun 21;14:1150068. doi: 10.3389/fendo.2023.1150068. eCollection 2023.
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Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes.解析空间大脑中的星形胶质细胞行为：原代星形胶质细胞的辐射反应。
Front Public Health. 2023 Apr 6;11:1063250. doi: 10.3389/fpubh.2023.1063250. eCollection 2023.
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MRTF may be the missing link in a multiscale mechanobiology approach toward macrophage dysfunction in space.在针对太空环境中巨噬细胞功能障碍的多尺度力学生物学方法中，MRTF可能是缺失的环节。
Front Cell Dev Biol. 2022 Sep 12;10:997365. doi: 10.3389/fcell.2022.997365. eCollection 2022.
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Effects of Simulated Microgravity on Wild Type and Marfan hiPSCs-Derived Embryoid Bodies.模拟微重力对野生型和马凡氏综合征人诱导多能干细胞来源的类胚体的影响。
Cell Mol Bioeng. 2021 Jun 7;14(6):613-626. doi: 10.1007/s12195-021-00680-1. eCollection 2021 Dec.
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Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice.模拟银河宇宙射线可改变破骨细胞中线粒体代谢，增加破骨细胞生成，导致小鼠骨小梁丢失。
Int J Mol Sci. 2021 Oct 28;22(21):11711. doi: 10.3390/ijms222111711.
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Simulated Microgravity Inhibits the Proliferation of Chang Liver Cells by Attenuation of the Major Cell Cycle Regulators and Cytoskeletal Proteins.模拟微重力通过衰减主要细胞周期调控因子和细胞骨架蛋白抑制 Chang 肝 细胞的增殖。
Int J Mol Sci. 2021 Apr 27;22(9):4550. doi: 10.3390/ijms22094550.
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[Mesenchymal stem cells and skin injury repair].[间充质干细胞与皮肤损伤修复]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Apr 25;38(2):387-392. doi: 10.7507/1001-5515.202011017.
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The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.航天辐射和微重力对生物系统和功能结果的单独和联合影响。
J Environ Sci Health C Toxicol Carcinog. 2021;39(2):129-179. doi: 10.1080/26896583.2021.1885283.
本文引用的文献
1
Actin flows in cell migration: from locomotion and polarity to trajectories.肌动蛋白在细胞迁移中的流动：从运动和极性到轨迹。
Curr Opin Cell Biol. 2016 Feb;38:12-7. doi: 10.1016/j.ceb.2016.01.003. Epub 2016 Jan 29.
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Effect of SDF-1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury.SDF-1/CXCR4轴对脊髓损伤后促红细胞生成素动员的移植骨髓间充质干细胞向损伤部位迁移的影响。
Int J Mol Med. 2015 Nov;36(5):1205-14. doi: 10.3892/ijmm.2015.2344. Epub 2015 Sep 14.
3
The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells.clinorotation对骨髓间充质干细胞增殖和分化的影响及机制。
Biochem Biophys Res Commun. 2015 May 1;460(2):327-32. doi: 10.1016/j.bbrc.2015.03.034. Epub 2015 Mar 21.
4
Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation.干细胞在外层空间微重力和地基微重力模拟条件下的行为。
Cell Biol Int. 2015 Jun;39(6):647-56. doi: 10.1002/cbin.10452. Epub 2015 Mar 9.
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Regulation of ICAM-1 in cells of the monocyte/macrophage system in microgravity.微重力下单核细胞/巨噬细胞系统细胞中细胞间黏附分子-1（ICAM-1）的调控
Biomed Res Int. 2015;2015:538786. doi: 10.1155/2015/538786. Epub 2015 Jan 13.
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The impact of microgravity and hypergravity on endothelial cells.微重力和超重对内皮细胞的影响。
Biomed Res Int. 2015;2015:434803. doi: 10.1155/2015/434803. Epub 2015 Jan 13.
7
RhoGTPases as key players in mammalian cell adaptation to microgravity.RhoGTP酶作为哺乳动物细胞适应微重力的关键因子。
Biomed Res Int. 2015;2015:747693. doi: 10.1155/2015/747693. Epub 2015 Jan 29.
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Cyclic mechanical stretching promotes migration but inhibits invasion of rat bone marrow stromal cells.周期性机械拉伸促进大鼠骨髓基质细胞迁移，但抑制其侵袭。
Stem Cell Res. 2015 Mar;14(2):155-64. doi: 10.1016/j.scr.2015.01.001. Epub 2015 Jan 17.
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Microgravity alters cancer growth and progression.微重力改变癌症的生长和进展。
Curr Cancer Drug Targets. 2014;14(4):394-406. doi: 10.2174/1568009614666140407113633.
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Lipid rafts control human melanoma cell migration by regulating focal adhesion disassembly.脂筏通过调节粘着斑的解体来控制人类黑色素瘤细胞的迁移。
Biochim Biophys Acta. 2013 Dec;1833(12):3195-3205. doi: 10.1016/j.bbamcr.2013.09.007. Epub 2013 Sep 20.
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