接受肺移植的成年囊性纤维化患者的骨矿物质密度和脂溶性维生素状况：一项初步研究。

Bone Mineral Density and Fat-Soluble Vitamin Status in Adults with Cystic Fibrosis Undergoing Lung Transplantation: A Pilot Study.

作者信息

Hubert Grace, Chung Theresa Tam, Prosser Connie, Lien Dale, Weinkauf Justin, Brown Neil, Goodvin Marianne, Jackson Kathy, Tabak Joan, Salgado Josette, Alzaben Abeer Salman, Mager Diana R

机构信息

a Nutrition Services, Alberta Health Services, Edmonton, AB.

b Department of Laboratory Medicine, University of Alberta, Edmonton, AB.

出版信息

Can J Diet Pract Res. 2016 Dec;77(4):199-202. doi: 10.3148/cjdpr-2016-014. Epub 2016 Jul 19.

DOI:10.3148/cjdpr-2016-014

PMID:27744736

Abstract

PURPOSE

Patients with cystic fibrosis (CF) often experience low bone mineral density (BMD) pre- and post-lung transplantation (LTX). The study purpose was to describe BMD and micronutrient status in adults with CF pre- and post-LTX.

METHODS

Twelve patients with CF (29 ± 8 years) were recruited from the CF clinic at the University of Alberta Lung Transplant Program. BMD and vitamins A, D, E, K status, and parathyroid hormone were measured pre- and post-LTX.

RESULTS

No significant differences pre- and post-LTX were observed at the different bone sites measured (lumber-spine, femoral-neck (FN), hip, and femoral-trochlea) (P > 0.05). BMD T-scores (<-2) was present in lumbar-spine, FN, hip, and femoral-trochlea in 33%, 17%, 17%, and 25% of individuals pre-LTX and 58%, 33%, 58%, and 33% of individuals post-LTX, respectively. More than 50% of patients had suboptimal vitamin K levels (PIVKA-II values >3 ng/mL) pre- and post-LTX.

CONCLUSION

Adults with CF pre- and post-LTX had reduced BMD and suboptimal vitamin K status.

摘要

目的

囊性纤维化（CF）患者在肺移植（LTX）前后常出现低骨矿物质密度（BMD）。本研究目的是描述CF成年患者LTX前后的BMD和微量营养素状况。

方法

从阿尔伯塔大学肺移植项目的CF诊所招募了12例CF患者（29±8岁）。在LTX前后测量BMD以及维生素A、D、E、K水平和甲状旁腺激素。

结果

在测量的不同骨部位（腰椎、股骨颈（FN）、髋部和股骨滑车），LTX前后未观察到显著差异（P>0.05）。LTX前，腰椎、FN、髋部和股骨滑车处BMD T值<-2的个体分别占33%、17%、17%和25%；LTX后，分别占58%、33%、58%和33%。LTX前后超过50%的患者维生素K水平欠佳（异常凝血酶原-II值>3 ng/mL）。