Hubert Grace, Chung Theresa Tam, Prosser Connie, Lien Dale, Weinkauf Justin, Brown Neil, Goodvin Marianne, Jackson Kathy, Tabak Joan, Salgado Josette, Alzaben Abeer Salman, Mager Diana R
a Nutrition Services, Alberta Health Services, Edmonton, AB.
b Department of Laboratory Medicine, University of Alberta, Edmonton, AB.
Can J Diet Pract Res. 2016 Dec;77(4):199-202. doi: 10.3148/cjdpr-2016-014. Epub 2016 Jul 19.
Patients with cystic fibrosis (CF) often experience low bone mineral density (BMD) pre- and post-lung transplantation (LTX). The study purpose was to describe BMD and micronutrient status in adults with CF pre- and post-LTX.
Twelve patients with CF (29 ± 8 years) were recruited from the CF clinic at the University of Alberta Lung Transplant Program. BMD and vitamins A, D, E, K status, and parathyroid hormone were measured pre- and post-LTX.
No significant differences pre- and post-LTX were observed at the different bone sites measured (lumber-spine, femoral-neck (FN), hip, and femoral-trochlea) (P > 0.05). BMD T-scores (<-2) was present in lumbar-spine, FN, hip, and femoral-trochlea in 33%, 17%, 17%, and 25% of individuals pre-LTX and 58%, 33%, 58%, and 33% of individuals post-LTX, respectively. More than 50% of patients had suboptimal vitamin K levels (PIVKA-II values >3 ng/mL) pre- and post-LTX.
Adults with CF pre- and post-LTX had reduced BMD and suboptimal vitamin K status.
囊性纤维化（CF）患者在肺移植（LTX）前后常出现低骨矿物质密度（BMD）。本研究目的是描述CF成年患者LTX前后的BMD和微量营养素状况。
从阿尔伯塔大学肺移植项目的CF诊所招募了12例CF患者（29±8岁）。在LTX前后测量BMD以及维生素A、D、E、K水平和甲状旁腺激素。
在测量的不同骨部位（腰椎、股骨颈（FN）、髋部和股骨滑车），LTX前后未观察到显著差异（P>0.05）。LTX前，腰椎、FN、髋部和股骨滑车处BMD T值<-2的个体分别占33%、17%、17%和25%；LTX后，分别占58%、33%、58%和33%。LTX前后超过50%的患者维生素K水平欠佳（异常凝血酶原-II值>3 ng/mL）。
CF成年患者LTX前后BMD降低，维生素K状况欠佳。
