疫苗抗体反应低的婴儿先天细胞因子反应发生了改变。
Infants with low vaccine antibody responses have altered innate cytokine response.
作者信息
Surendran Naveen, Nicolosi Ted, Pichichero Michael
机构信息
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester Regional Health System, 1425 Portland Ave, Rochester, NY, United States.
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester Regional Health System, 1425 Portland Ave, Rochester, NY, United States; Legacy Pediatrics, Rochester, NY, United States.
出版信息
Vaccine. 2016 Nov 11;34(47):5700-5703. doi: 10.1016/j.vaccine.2016.09.050. Epub 2016 Oct 13.
Abstract
We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.
摘要
我们最近发现，由于先天性和适应性免疫反应改变，10%的婴儿对大多数常规儿科基础疫苗接种的抗体反应水平低于保护阈值。我们将这些婴儿称为低疫苗反应者（LVR）。在此，我们报告新的数据表明，与正常疫苗反应者（NVR）婴儿相比，用TLR7/8激动剂-R848刺激LVR婴儿的外周血单核细胞（PBMC），会显著降低IFN-α、IL-12p70和IL-1β水平，同时诱导更高水平的CCL5（调节激活正常T细胞表达和分泌因子）。
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