产前利多卡因对听觉脑干诱发电位的影响。
Effect of prenatal lignocaine on auditory brain stem evoked response.
作者信息
Bozynski M E, Schumacher R E, Deschner L S, Kileny P
机构信息
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor.
出版信息
Arch Dis Child. 1989 Jul;64(7 Spec No):934-8. doi: 10.1136/adc.64.7_spec_no.934.
To test the hypothesis that there would be a positive correlation between the interpeak wave (I-V) interval as measured by auditory brain stem evoked response and the ratio of umbilical cord blood arterial to venous lignocaine concentrations in infants born after maternal epidural anaesthesia, 10 normal infants born at full term by elective caesarean section were studied. Umbilical cord arterial and venous plasma samples were assayed for lignocaine, and auditory brain stem evoked responses were elicited at 35 and 70 dB at less than 4 (test 1) and greater than or equal to 48 hours (test 2). Mean wave I-V intervals were prolonged in test 1 when compared with test 2. Linear regression showed the arterial:venous ratio accounted for 66% (left ear) and 43% (right ear) of the variance in test 1 intervals. No association was found in test 2. In newborn infants, changes in serial auditory brain stem evoked response tests occur after maternal lignocaine epidural anaesthesia and these changes correlate with blood lignocaine concentrations.
为验证如下假设
在接受母体硬膜外麻醉后出生的婴儿中，通过听觉脑干诱发电位测量的峰间期（I-V）与脐血动脉血和静脉血中利多卡因浓度的比值之间存在正相关，我们对10例择期剖宫产足月出生的正常婴儿进行了研究。检测脐动脉和脐静脉血浆样本中的利多卡因，并在小于4小时（测试1）和大于或等于48小时（测试2）时，分别在35分贝和70分贝下引出听觉脑干诱发电位。与测试2相比，测试1中的平均I-V间期延长。线性回归显示，在测试1的间期内，动脉血与静脉血的比值分别解释了66%（左耳）和43%（右耳）的变异。在测试2中未发现相关性。在新生儿中，母体利多卡因硬膜外麻醉后会出现系列听觉脑干诱发电位测试的变化，且这些变化与血液中利多卡因浓度相关。
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