Wang Lei, Wang Yu, Li Peng-Ping, Wang Rui, Zhu Yue, Zheng Fang, Li Lin, Cui Jiu-Jie, Wang Li-Wei
Department of Oncology, Shanghai General Hospital of Nanjing Medical University, Shanghai, 201620, China.
Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, 201620, China.
Tumour Biol. 2016 Dec;37:16207–16213. doi: 10.1007/s13277-016-5457-4. Epub 2016 Oct 17.
SAV1 is a human homolog of salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein for Hpo and Warts. SAV1 is known to be a tumor suppressor, but its clinical and prognostic implications remain elusive. This study aimed at evaluating the prognostic significance and associated expression of SAV1 in pancreatic ductal adenocarcinoma (PDAC) patients. The expression of SAV1 in tissue specimens of PDAC patients were assayed with immunohistochemistry on a tissue microarray. The correlations between SAV1 expression and clinicopathological characteristics were analyzed by Pearson's chi-square test, Fisher's exact test, and Spearman's rank. The prognostic factors for overall survival were analyzed by univariate and multivariate Cox regression. The percentage of SAV1 expression in PDAC (50.6 %) was significantly lower than those in paratumor tissues (69.9 %) (P = 0.017). Expression of SAV1 was only significantly correlated with histological differentiation (P = 0.025) and N classification (P = 0.009). On multivariate analysis, elevated expression of SAV1 and N0 was a significant favorable prognostic factor of OS. Our study demonstrated for the first time that lower expression of SAV1 might be involved in the progression of PDAC, suggesting that SAV1 may be a potential prognostic marker and target for PDAC therapy.
SAV1是果蝇salvador的人类同源物，包含两个称为WW结构域的蛋白质-蛋白质相互作用模块，并作为Hpo和Warts的支架蛋白发挥作用。已知SAV1是一种肿瘤抑制因子，但其临床和预后意义仍不明确。本研究旨在评估SAV1在胰腺导管腺癌（PDAC）患者中的预后意义及相关表达情况。通过组织芯片免疫组织化学法检测PDAC患者组织标本中SAV1的表达。采用Pearson卡方检验、Fisher精确检验和Spearman秩相关分析SAV1表达与临床病理特征之间的相关性。通过单因素和多因素Cox回归分析总生存的预后因素。PDAC中SAV1的表达百分比（50.6%）显著低于癌旁组织（69.9%）（P = 0.017）。SAV1的表达仅与组织学分化（P = 0.025）和N分期（P = 0.009）显著相关。多因素分析显示，SAV1表达升高和N0是总生存的显著有利预后因素。我们的研究首次表明，SAV1表达降低可能参与了PDAC的进展，提示SAV1可能是PDAC治疗的潜在预后标志物和靶点。
