Influence of nonsteroidal antiphlogistics on mouse ear inflammation induced with croton oil.

The oedema disk technique was used to study the effects of orally administered nonsteroidal antiphlogistics (piroxicam, phenylbutazone, proquazone, azapropazone and nifluminic acid) on the inflammation induced with croton oil in the mouse ear. This method was demonstrated to be suitable for the detection of an antiphlogistic effect. The substances examined exerted a statistically significant extent of inhibition in a dose-dependent manner. Oedema inhibition of about 50% was achieved with a dose of 10 mg/kg piroxicam; inhibition of more than 30% necessitated the administration of 10 mg/kg proquazone, 10 mg/kg nifluminic acid or 50 mg/kg azapropazone. Following administration of 90 mg/kg phenylbutazone, an inhibition of only 22.4% was observed.