高度近视与糖尿病视网膜病变：对高度近视性屈光参差糖尿病患者的对侧眼研究

HIGH MYOPIA AND DIABETIC RETINOPATHY: A Contralateral Eye Study in Diabetic Patients With High Myopic Anisometropia.

作者信息

Bazzazi Nooshin, Akbarzadeh Siamak, Yavarikia Minoo, Poorolajal Jalal, Fouladi Daniel F

机构信息

*Department of Ophthalmology, Farshchian Teaching Center, Hamadan University of Medical Sciences, Hamadan, Iran; †Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran; and ‡Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Retina. 2017 Jul;37(7):1270-1276. doi: 10.1097/IAE.0000000000001335.

DOI:10.1097/IAE.0000000000001335

PMID:27749693

Abstract

PURPOSE

To examine an association between high myopia and diabetic retinopathy (DR) in diabetic patients with high myopic anisometropia.

METHODS

A total of 116 white diabetic patients (232 eyes) with high myopia (spherical equivalent > -5.00 diopters, D) anisometropia (difference ≥ -6 D) were enrolled in this cross-sectional, contralateral eye study. The frequency of DR was compared between the high myopic and the contralateral eyes.

RESULTS

Compared with the fellow eyes, DR was significantly less frequent in high myopic side (27.6% vs. 100%, P < 0.001; relative risk, 0.28 with 95% confidence interval of 0.21-0.37). Similar significant trends were found for the incidence of nonproliferative (27.6% vs. 69%, P < 0.001) and proliferative DR (0% vs. 31%, P < 0.001). Diabetic retinopathy was also less severe in the same group.

CONCLUSION

Using a contralateral eye study design prevented the influence of potential confounding factors inherent in similar previous case-control studies. On this basis, a protective role for high myopia against DR was established.

摘要

目的

研究患有高度近视性屈光参差的糖尿病患者中高度近视与糖尿病视网膜病变（DR）之间的关联。

方法

本横断面、对侧眼研究共纳入116例患有高度近视（等效球镜度数＞-5.00屈光度，D）性屈光参差（差值≥-6D）的白人糖尿病患者（232只眼）。比较高度近视眼和对侧眼的DR发生率。

结果

与对侧眼相比，高度近视侧的DR发生率显著更低（27.6%对100%，P＜0.001；相对危险度，0.28，95%置信区间为0.21-0.37）。非增殖性DR（27.6%对69%，P＜0.001）和增殖性DR（0%对31%，P＜0.001）的发生率也呈现类似的显著趋势。同一组中糖尿病视网膜病变也较轻。